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Synthesis
DOI: 10.1055/a-2412-9481
paper

Ir-Catalyzed Leuckart-Type Reductive Amination of Carbonyls

Renshi Luo 
1   School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, China
,
Liang Liu
2   School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, China (Ringgold ID: RIN74554)
,
Jinghui Tong
2   School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, China (Ringgold ID: RIN74554)
,
Lu Ouyang
3   School of Pharmacy, Gannan Medical University, Ganzhou, China (Ringgold ID: RIN74554)
,
Jianhua Liao
2   School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, China (Ringgold ID: RIN74554)
› Author AffiliationsSupported by: Education Department of Guangdong 2023ZDZX2059
Supported by: Gannan Medical University QD202019, QD202106, TD2021YX05
Supported by: Shaoguan University 408/9900064703
Supported by: National Natural Science Foundation of China 22161004
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Formamides are fundamental motifs prevalent in drugs, pesticides, dyes, fragrances. Herein, we described an Ir-catalyzed Leuckart-type reductive amination of carbonyls, delivering formamides in moderate to excellent yields. In this process, the ammonium formate was used as N-formylated reagent to produce the formamide products. This protocol provides a new procedure for formamide synthesis.



Publication History

Received: 10 July 2024

Accepted after revision: 10 September 2024

Accepted Manuscript online:
10 September 2024

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