Synthesis
DOI: 10.1055/a-2410-2039
short review

A Practical Guide to SuFEx Chemistry: An Overview of S(VI)-SuFEx Linkers and their Reactivity

1   Department of Pharmacy, University of Bari, Bari, Italy
,
Michael Andresini
1   Department of Pharmacy, University of Bari, Bari, Italy
,
Philipp Natho
1   Department of Pharmacy, University of Bari, Bari, Italy
,
Defne Serbetci
1   Department of Pharmacy, University of Bari, Bari, Italy
,
Laura Marraffa
1   Department of Pharmacy, University of Bari, Bari, Italy
› Author Affiliations

Sulfur(VI)-fluoride exchange (SuFEx) is a second generation, metal-free click chemistry concept introduced by Sharpless in 2014. Since the introduction of the concept, a large variety of synthetic methodologies to S(VI)-SuFEx hubs, and their derivatization with oxygen-, nitrogen-, and carbon-based nucleophiles have been developed. Herein, we provide a concise and practical overview for their preparation, SuFExability, inclusive of which substituents are tolerated. The stereoselective synthesis of aza-derivatives is also discussed.



Publication History

Received: 01 August 2024

Accepted: 05 September 2024

Accepted Manuscript online:
05 September 2024

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