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Drug Res (Stuttg) 2024; 74(07): 347-359
DOI: 10.1055/a-2361-2895
Original Article

Assessing the Compatibility of Menatetrenone with Excipients: A Spectroscopic Approach and Implication in Drug Formulation Development

Widhilika Singh
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Poonam Kushwaha
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Shom Prakash Kushwaha
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
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Abstract

An experiment was conducted to evaluate the compatibility of menatetrenone with selected pharmaceutical excipients. Fourier Transform Infrared Spectroscopy (FTIR) was used to assess drug-excipient compatibility. The present research systematically investigates the FTIR spectrum of each chemical compound separately and their physical blends, analyzing for possible shifts, alterations or novel peak that may indicate chemical interactions. This study aims to utilize spectral data interpretation to detect potential compatibility problems that may occur while design and production of menatetrenone containing dosage forms ensuring their increased stability and effectiveness. The FTIR results demonstrated that all the pharmaceutical excipients were compatible with menatetrenone. In conclusion, the compatibility of pharmaceutical excipients with menatetrenone was successfully assessed using FTIR that will aid in future design of formulations containing menatetrenone as therapeutic moiety.

Keywords

menatetrenone - fourier transform infrared spectroscopy - compatibility study - vitamin K2 - menaquinone-4 analysis - drug-excipient interaction


Publication History

Received: 14 May 2024

Accepted: 26 June 2024

Article published online:
02 August 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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