Planta Med 2024; 90(11): 876-884
DOI: 10.1055/a-2344-8841
Biological and Pharmacological Activity
Original Papers

Fuʼcupping Physical Permeation-Enhancing Technique Enhances the Therapeutic Efficacy of Corydalis yanhusuo Gel Plaster

Guoqiong Cao
1   College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
2   National Engineering Technology Research Center for Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
,
Zilan Zhu
4   UCL School of Pharmacy, University College London, London, UK
,
Dingyi Yang
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
,
Wenyu Wu
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
,
Fangfang Yang
1   College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
2   National Engineering Technology Research Center for Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
,
Yao Liu
1   College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
2   National Engineering Technology Research Center for Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
,
Jian Xu
1   College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
2   National Engineering Technology Research Center for Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
,
Yongping Zhang
1   College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
2   National Engineering Technology Research Center for Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
3   Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China
› Author Affiliations
This work was supported by grants from the following projects: National Nature Science Foundation of China (81 873 020), National Engineering Technology Research Center for Miao Medicine Improved Ability (QKHZYD[2023]006), Engineering Research Center of New Dosage Form and New Preparation of Traditional Chinese Medicine (Miao medicine) in Higher Education Institutions of Guizhou Province (QJJ[2022]022), The Sixth Batch of Guizhou Province High-level Innovative Talent Training Program, and The High-level Innovative Talents of Guizhou Province of China (Qian Ke He Platform and Talent -GCC[2023]037).

Abstract

Corydalis yanhusuo, a traditional Chinese medicine, is widely used to treat various pains, and its active ingredients are alkaloids. This study aimed to develop a new type of transdermal gel plaster containing the extract of C. yanhusuo. Studies have shown that Fuʼcupping physical permeation-enhancing technique can promote the penetration of alkaloids and improve the efficacy of drugs. A transdermal gel plaster containing the extract of C. yanhusuo was prepared and optimized using an orthogonal experimental design. The skin permeation ability of the gel plaster was studied in vitro, while the anti-inflammatory and analgesic effects of the prepared patch alone or with Fuʼcupping physical permeation-enhancing technique were evaluated in a rat model. The formulation of a gel plaster containing C. yanhusuo extract was successfully prepared with an optimized composition consisting of glycerin (15 g), sodium polyacrylate (2 g), silicon dioxide (0.3 g), ethanol (2 g), aluminum oxide (0.1 g), citric acid (0.05 g), the C. yanhusuo extract (3 g), and water (15 g). The cumulative transdermal permeation of dehydrocorydaline, corypalmine, tetrahydropalmatine, and corydaline in 24 h was estimated to be 569.7 ± 63.2, 74.5 ± 13.7, 82.4 ± 17.2, and 38.9 ± 8.1 µg/cm2, respectively. The in vitro diffusion of dehydrocorydaline and corydaline followed the zero-order kinetics profile, while that of corypalmine and tetrahydropalmatine followed a Higuchi equation. The prepared gel plaster significantly reduced paw swelling, downregulated inflammatory cytokines, and mitigated pain induced by mechanical or chemical stimuli. The Fuʼcupping physical permeation-enhancing technique further improved the anti-inflammatory and analgesic effects of the patch. The combined application of the Fuʼcupping physical permeation-enhancing technique and the alkaloid gel plaster may be effective against inflammation and pain.



Publication History

Received: 12 November 2023

Accepted after revision: 14 June 2024

Accepted Manuscript online:
14 June 2024

Article published online:
19 July 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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