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Synthesis
DOI: 10.1055/a-2315-1934
paper

Photocatalytic Annulation of Enaminones with Thioureas for the Synthesis of 2-Aminothiazoles via Tandem C–S and C–N Bond Formation

Qihui Huang
,
Changfeng Wan∗
,
Jie-Ping Wan∗
The authors thank the National Natural Science Foundation of China (Grant: 22161022) for funding.
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Abstract

Visible-light photocatalytic reactions between enaminones and thioureas leading to thiazole products have been achieved. The annulation process consists of tandem C–S and C–N bond formation by running reactions under air atmosphere at ambient temperature. Broad substrate tolerance of the sustainable protocol has been verified by the practical synthesis of divergent thiazoles with both monocyclic and fused cyclic structures.

Key words

photocatalysis - enaminones - thiourea - annulation - thiazoles

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2315-1934.
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Publication History

Received: 01 April 2024

Accepted after revision: 26 April 2024

Accepted Manuscript online:
26 April 2024

Article published online:
15 May 2024

© 2024. Thieme. All rights reserved

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