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Thromb Haemost
DOI: 10.1055/a-2305-6631
Stroke, Systemic or Venous Thromboembolism

Association of Cardiovascular Health with the Incidence of Venous Thromboembolism: A Prospective Study of 275,149 Participants from the UK Biobank

Benhui Liang   #
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
2   National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Lihuang Zha   #
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
2   National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Baohua Peng
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Qin Chen
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Mukamengjiang Juaiti
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Xiaofang Zeng
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Yilu Feng
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Zaixin Yu
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
2   National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
,
Yiyang Tang
1   Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
2   National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China under grant No. 82070055 and No. 82100071, Hunan Provincial Natural Science Foundation of China under grant No. 2022JJ30981 and No. 2022JJ40769, and Fundamental Research Funds for the Central Universities of Central South University under grant No. 2023ZZTS0550.
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Abstract

Background The Life's Essential 8 (LE8) score, recently proposed by the American Heart Association, represents a new paradigm for evaluating cardiovascular health (CVH). We aimed to explore the association between CVH, estimated using LE8, and venous thromboembolism (VTE) incidence.

Methods A total of 275,149 participants were recruited from the UK Biobank and divided into high (LE8 score ≥ 80), moderate (LE8 score < 80 but ≥ 50), and low (LE8 score < 50) CVH groups. Restricted cubic spline analysis, the Kaplan–Meier method, and the Cox proportional hazards model were used to explore the association between CVH and VTE. The genetic predisposition to VTE was assessed with a polygenic risk score. Sensitivity analyses were performed to validate the results.

Results During a median follow-up of 12.56 years, VTE developed in 506 (4.09%), 6,069 (2.78%), and 720 (1.66%) participants with low, moderate, and high CVH levels, respectively. Compared with the low CVH group, participants in the moderate and high CVH groups had a 23% (hazard ratio [HR]: 0.77; 95% confidence interval [CI]: 0.71–0.85) and 41% (HR: 0.59; 95% CI: 0.52–0.66) lower risk of VTE, respectively, after adjusting for demographic characteristics, medical history, socioeconomic status, and genetic predisposition. This association remained robust in multiple sensitivity analyses. Higher CVH levels led to a more pronounced reduction in the risk of VTE in females and could appreciably offset the genetic risk of VTE.

Conclusion Higher CVH levels were significantly associated with a lower incidence of VTE, encouraging efforts to increase LE8 scores in individuals.

Keywords

cardiovascular health - Life's Essential 8 - venous thromboembolism - genetic predisposition

Data Availability Statement

The data relevant to this study can be accessed from the UK Biobank Resource, available at www.ukbiobank.ac.uk. Please note that an application and subsequent official authorization are required to obtain the data.


Authors' Contribution

This study was conceived and designed by Y.T. B.L. and L.Z. were responsible for the extraction and analysis of the clinical data, as well as drafting the manuscript. B.P. and Q.C. assisted in the statistical analysis. M.J. and X.Z. contributed to implementing statistical methods and offered constructive suggestions. The manuscript was revised by Y.F. and Z.Y., who also participated in interpreting the results. All authors reviewed and approved the final manuscript.


# These authors contributed equally.


Supplementary Material



Publication History

Received: 03 January 2024

Accepted: 11 April 2024

Accepted Manuscript online:
12 April 2024

Article published online:
07 May 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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