Download PDF
Diabetes aktuell 2024; 22(02): 46-47
DOI: 10.1055/a-2252-5874
Gesellschaft
VDBD
Der Verband der Diabetes-Beratungs- und Schulungsberufe in Deutschland informiert

Pathomechanismen von Diabetes und Krebs

Präventive Maßnahmen und Empfehlungen
Christine Klühs
› Further Information
Also available at
    Permissions and Reprints

Diabetes und Krebs betreffen mit steigender Prävalenz einen Großteil der Bevölkerung in den Industrie- und Schwellenländern. Überernährung sowie verminderte körperliche Aktivität mit konsekutivem Übergewicht sind mit einem deutlich erhöhten Risiko für Diabetes und Krebs verbunden. In diesem Artikel werden gemeinsame Pathomechanismen von Krebs und Diabetes erläutert und auf präventive Maßnahmen und Empfehlungen eingegangen.



Publication History

Article published online:
05 April 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Krebs in Deutschland für 2019/2020. Robert Koch-Institut, Berlin 2023
  • 2 Vigneri P. et al Diabetes and cancer. Endocr Relat Cancer 2009; 16: 1103-1123
    CrossrefPubMedGoogle Scholar
  • 3 Pinheiro LC. et al Diabetes and cancer co-management: patient-reported challenges, needs, and priorities. Supportive Care in Cancer 2023; 31: 145
    CrossrefPubMedGoogle Scholar
  • 4 Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70
    CrossrefPubMedGoogle Scholar
  • 5 Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674
    CrossrefPubMedGoogle Scholar
  • 6 Hanahan D. The hallmarks of cancer. Cancer Discov 2022; 12: 31-46
    CrossrefPubMedGoogle Scholar
  • 7 Heuson JC. et al Influence of insulin administration on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in intact, oophorectomized, and hypophysectomized rats. Cancer Research 1972; 32: 233-238
    PubMedGoogle Scholar
  • 8 Haim W. et al The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action, Trends in Endocrinology & Metabolism. 2006; 17: 236-242
    PubMedGoogle Scholar
  • 9 Giovannucci E. et al Diabetes and cancer: a consensus report. Diabetes Care 2010; 33: 1674-1685
    CrossrefPubMedGoogle Scholar
  • 10 Schienkiewitz A. et al Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Natr 2006; 84: 427-433
    CrossrefGoogle Scholar
  • 11 van Kruijsdijk RC. et al Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev 2009; 18: 2569-2578
    CrossrefPubMedGoogle Scholar
  • 12 Louie MW. et al Luminescent rhenium(I) polypyridine complexes appended with an alpha-D-glucose moiety as novel biomolecular and cellular probes. Chemistry 2011; 17: 8304-8308
    CrossrefPubMedGoogle Scholar
  • 13 Sona MF. et al Type 1 diabetes mellitus and risk of cancer: a meta-analysis of observational studies. Jpn J Clin Oncol 2018; 48: 426-433
    CrossrefPubMedGoogle Scholar
  • 14 Leitlinienprogramm Onkologie. S3-Leitlinie Palliativmedizin, Version 2.2, September 2020, S. 48
  • 15 Alenzi EO. et al The association of hyperglycemia and diabetes mellitus and the risk of chemotherapy-induced neutropenia among cancer patients: A systematic review with metaanalysis. J Diabetes Complications 2017; 31: 2
    CrossrefPubMedGoogle Scholar
  • 16 Harris D. et al Glucocorticoid-induced hyperglycemia is prevalent and unpredictable for patients undergoing cancer therapy: an observational cohort study. Curr Oncol 2013; 20: e532-e538
    CrossrefPubMedGoogle Scholar
  • 17 Hershey D. et al Predictors of diabetes self-management in older adults receiving chemotherapy. Cancer Nurs 2014; 37: 97-105
    CrossrefPubMedGoogle Scholar
  • 18 Gerards MC. et al Impact of hyperglycemia on the efficacy of chemotherapy – A systematic review of preclinical studies. Crit Rev Oncol Hematol 2017; 113: 235-241
    CrossrefPubMedGoogle Scholar
  • 19 Attili V. et al Impact of diabetes on cancer chemotherapy outcome: A retrospective analysis. International Journal of Diabetes in Developing Countries 2007; 27 (4)
    Google Scholar
  • 20 https://www.esmo.org/content/download/133758/2490221/1/DE-ESMO-Patientenleitlinie-Immuntherapie-bedingte-Nebenwirkungen-und-ihr-Management.pdf letzter Zugriff: 08.03.2024