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Synthesis 2023; 55(24): 4091-4095
DOI: 10.1055/a-2122-4287
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Improved Syntheses of an Arseno-Fatty Acid (As-FA 362) and an Arseno-Hydrocarbon (As-HC 444)

Miguel A. Chacon-Teran
a   Department of Chemistry and Biochemistry, University of California, Merced, 5200 Lake Rd, Merced, CA 95343, USA
,
Shubhra Bhattacharjee
b   Department of Civil, Environmental and Construction Engineering, Texas Tech University, Lubbock, TX 79409, USA
,
Jeremy D. Bailoo
c   Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
,
Amrika Deonarine∗
b   Department of Civil, Environmental and Construction Engineering, Texas Tech University, Lubbock, TX 79409, USA
,
Michael Findlater  ∗
a   Department of Chemistry and Biochemistry, University of California, Merced, 5200 Lake Rd, Merced, CA 95343, USA
› Author AffiliationsThis research was supported by National Institute of Environmental Health Sciences grants R03ES033333 (to A.D., J.B., and M.F.) and R03ES034194 (to A.D. and J.B.).
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Abstract

Robust and reliable synthetic methods have been developed for the preparation of an arseno-fatty acid (As-FA362) and an arseno-hydrocarbon (As-HC444). An improved route to access the starting materials necessary for the new synthetic routes is also disclosed. With these improvements, an increased accessibility to arsenic-containing compounds is anticipated, which may be deployed as standards required for the development of quantitative methods in biological matrices. For the first time, stability data for these compounds are reported. With these results in hand, data on the elimination profile, bioaccumulation potential and patho-behavioral and physiological consequences of these organoarsenicals are planned.

Key words

arsenic - arsenolipids - synthesis - fatty acids


Publication History

Received: 30 May 2023

Accepted after revision: 03 July 2023

Accepted Manuscript online:
04 July 2023

Article published online:
17 August 2023

© 2023. Thieme. All rights reserved

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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