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Int J Sports Med 2023; 44(07): 463-472
DOI: 10.1055/a-1982-9902
Review

Muscle Power in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Simone Pancera 
1   IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
,
Nicola Francesco Lopomo
2   Department of Information Engineering, University of Brescia, Brescia, Italy
,
Riccardo Buraschi
1   IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
,
Joel Pollet
1   IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
,
Paolo Pedersini
1   IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
,
Stefano Giuseppe Lazzarini 
1   IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
,
Luca Nicola Cesare Bianchi
1   IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
› Author Affiliations Funding Information Italian Ministry of Health — Ricerca Corrente 2022
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Abstract

This study aimed to review the impact of training on muscle power in patients with chronic obstructive pulmonary disease (COPD). Randomized controlled trials evaluating the effects of exercise-based interventions on limbs muscle power and rate of force development in COPD patients were investigated. Five international databases were searched until October 2022. Meta-analyses were performed calculating the mean difference or standardized mean difference. Risk of bias in studies was assessed using Cochrane Risk of Bias tool 2.0. A total of nine studies were included in the analysis. There were concerns about risk of bias in seven out of nine studies. Comparison of exercising and non-exercising groups showed a significant effect of exercise in improving muscle power (P=0.0004) and rate of force development (P<0.001), in five and three trials, respectively. Four studies comparing different trainings showed no significant results on muscle power (P=0.45). Eight to 16 weeks of exercise-based intervention versus no intervention might be beneficial to enhance upper and lower limbs muscle power and rate of force development in people with COPD. In contrast, muscle power did not improve when different training modalities were compared. Future studies performing power training in COPD patients are encouraged.

Key words

COPD - resistance training - pulmonary rehabilitation - muscle function - muscle power

Supplementary Material



Publication History

Received: 22 June 2022

Accepted: 07 November 2022

Article published online:
17 February 2023

© 2023. Thieme. All rights reserved.

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  • References

  • 1 Adeloye D, Song P, Zhu Y. et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: A systematic review and modelling analysis. Lancet Respir Med 2022; 10: 447-458
    CrossrefPubMedGoogle Scholar
  • 2 Maltais F, Decramer M, Casaburi R. et al. An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2014; 189: e15-e62
    CrossrefPubMedGoogle Scholar
  • 3 Seymour J, Spruit M, Hopkinson N. et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J 2010; 36: 81-88
    CrossrefPubMedGoogle Scholar
  • 4 Evans RA, Kaplovitch E, Beauchamp MK. et al. Is quadriceps endurance reduced in COPD? A systematic review. Chest 2015; 147: 673-684
    CrossrefPubMedGoogle Scholar
  • 5 Marklund S, Bui K-L, Nyberg A. Measuring and monitoring skeletal muscle function in COPD: current perspectives. Int J Chron Obstruct Pulmon Dis 2019; 14: 1825-1838
    CrossrefPubMedGoogle Scholar
  • 6 Izquierdo M, Ibañez J, Gorostiaga E. et al. Maximal strength and power characteristics in isometric and dynamic actions of the upper and lower extremities in middle-aged and older men. Acta Physiol Scand 1999; 167: 57-68
    CrossrefPubMedGoogle Scholar
  • 7 Alcazar J, Guadalupe-Grau A, García-García FJ. et al. Skeletal muscle power measurement in older people: a systematic review of testing protocols and adverse events. J Gerontol A Biol Sci Med Sci 2018; 73: 914-924
    CrossrefPubMedGoogle Scholar
  • 8 Reid KF, Fielding RA. Skeletal muscle power: a critical determinant of physical functioning in older adults. Exerc Sport Sci Rev 2012; 40: 4-12
    CrossrefPubMedGoogle Scholar
  • 9 Bissolotti L, Rota M, Calza S. et al. Relationship between lower limbs performance and spinal alignment in Parkinson’s disease patients: an observational study with cross sectional design. J Clin Med 2022; 11: 3775
    CrossrefPubMedGoogle Scholar
  • 10 Butcher SJ, Pikaluk BJ, Chura RL. et al. Associations between isokinetic muscle strength, high-level functional performance, and physiological parameters in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2012; 7: 537-542
    CrossrefPubMedGoogle Scholar
  • 11 Bui K-L, Maia N, Saey D. et al. Reliability of quadriceps muscle power and explosive force, and relationship to physical function in people with chronic obstructive pulmonary disease: an observational prospective multicenter study. Physiother Theory Pract 2021; 37: 945-953
    CrossrefPubMedGoogle Scholar
  • 12 Hernández M, Zambom-Ferraresi F, Cebollero P. et al. The relationships between muscle power and physical activity in older men with chronic obstructive pulmonary disease. J Aging Phys Act 2017; 25: 360-366
    CrossrefPubMedGoogle Scholar
  • 13 Frykholm E, Gephine S, Saey D. et al. Isotonic quadriceps endurance is better associated with daily physical activity than quadriceps strength and power in COPD: An international multicentre cross-sectional trial. Sci Rep 2021; 11: 11557
    CrossrefPubMedGoogle Scholar
  • 14 Navarro-Cruz R, Alcazar J, Rodriguez-Lopez C. et al. The effect of the stretch-shortening cycle in the force-velocity relationship and its association with physical function in older adults with COPD. Front Physiol 2019; 10: 316
    CrossrefPubMedGoogle Scholar
  • 15 Maffiuletti NA, Aagaard P, Blazevich AJ. et al. Rate of force development: physiological and methodological considerations. Eur J Appl Physiol 2016; 116: 1091-1116
    CrossrefPubMedGoogle Scholar
  • 16 Corbellini C, Rossino E, Massaccesi R. et al. Improvements in perimeter thoracic mobility on patients with COPD after pulmonary rehabilitation: A case series. Electron J Gen Med 2022; 19: em361
    CrossrefPubMedGoogle Scholar
  • 17 Spruit MA, Singh SJ, Garvey C. et al. An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation. Am J Respir Crit Care Med 2013; 188: e13-e64
    CrossrefPubMedGoogle Scholar
  • 18 Hopkinson NS, Tennant RC, Dayer MJ. et al. A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease. Respir Res 2007; 8: 25
    CrossrefPubMedGoogle Scholar
  • 19 Reid KF, Pasha E, Doros G. et al. Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties. Eur J Appl Physiol 2014; 114: 29-39
    CrossrefPubMedGoogle Scholar
  • 20 American College of Sports Medicine Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2009; 41: 687-708
    CrossrefPubMedGoogle Scholar
  • 21 Pancera S, Lopomo NF, Bianchi LNC. et al. Isolated resistance training programs to improve peripheral muscle function in outpatients with chronic obstructive pulmonary diseases: A systematic review. Healthcare 2021; 9: 1397
    CrossrefPubMedGoogle Scholar
  • 22 O’Shea SD, Taylor NF, Paratz JD. Progressive resistance exercise improves muscle strength and may improve elements of performance of daily activities for people with COPD: A systematic review. Chest 2009; 136: 1269-1283
    CrossrefPubMedGoogle Scholar
  • 23 Liao WH, Chen JW, Chen X. et al. Impact of resistance training in subjects with COPD: A systematic review and meta-analysis. Respir Care 2015; 60: 1130-1145
    CrossrefPubMedGoogle Scholar
  • 24 Li P, Li J, Wang Y. et al. Effects of exercise intervention on peripheral skeletal muscle in stable patients with COPD: A systematic review and meta-analysis. Front Med 2021; 8: 766841
    CrossrefPubMedGoogle Scholar
  • 25 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021; 372: n71
    CrossrefPubMedGoogle Scholar
  • 26 Vogelmeier CF, Criner GJ, Martinez FJ. et al. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology 2017; 22: 575-601
    CrossrefPubMedGoogle Scholar
  • 27 Aagaard P, Simonsen EB, Andersen JL. et al. Increased rate of force development and neural drive of human skeletal muscle following resistance training. J Appl Physiol (1985) 2002; 93: 1318-1326
    CrossrefPubMedGoogle Scholar
  • 28 Ouzzani M, Hammady H, Fedorowicz Z. et al. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016; 5: 1-10
    CrossrefPubMedGoogle Scholar
  • 29 Alcazar J, Losa-Reyna J, Rodriguez-Lopez C. et al. Effects of concurrent exercise training on muscle dysfunction and systemic oxidative stress in older people with COPD. Scand J Med Sci Sports 2019; 29: 1591-1603
    CrossrefPubMedGoogle Scholar
  • 30 Gloeckl R, Jarosch I, Bengsch U. et al. What’s the secret behind the benefits of whole-body vibration training in patients with COPD? A randomized, controlled trial. Respir Med 2017; 126: 17-24
    CrossrefPubMedGoogle Scholar
  • 31 Zambom-Ferraresi F, Cebollero P, Gorostiaga E. et al Effects of combined resistance and endurance training versus resistance training alone on strength, exercise capacity, and quality of life in patients with COPD. J Cardiopulm Rehabil Prev 2015; 35: 446-453
    CrossrefPubMedGoogle Scholar
  • 32 Sterne JAC, Savović J, Page MJ. et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019; 366: l4898
    CrossrefPubMedGoogle Scholar
  • 33 Schulté B, Nieborak L, Leclercq F. et al. The comparison of high-intensity interval training versus moderate-intensity continuous training after coronary artery bypass graft: A systematic review of recent studies. J Cardiovasc Dev Dis 2022; 9: 328
    CrossrefPubMedGoogle Scholar
  • 34 Bourbeau J, De Sousa Sena R, Taivassalo T. et al. Eccentric versus conventional cycle training to improve muscle strength in advanced COPD: A randomized clinical trial. Respir Physiol Neurobiol 2020; 276: 103414
    CrossrefPubMedGoogle Scholar
  • 35 Gloeckl R, Schneeberger T, Leitl D. et al. Whole-body vibration training versus conventional balance training in patients with severe COPD-a randomized, controlled trial. Respir Res 2021; 22: 138
    CrossrefPubMedGoogle Scholar
  • 36 Hoff J, Tjønna A, Steinshamn S. et al. Maximal strength training of the legs in COPD: A therapy for mechanical inefficiency. Med Sci Sports Exerc 2007; 39: 220-226
    CrossrefPubMedGoogle Scholar
  • 37 Kongsgaard M, Backer V, Jørgensen K. et al. Heavy resistance training increases muscle size, strength and physical function in elderly male COPD-patients – pilot study. Respir Med 2004; 98: 1000-1007
    CrossrefPubMedGoogle Scholar
  • 38 van Wetering CR, Hoogendoorn M, Broekhuizen R. et al. Efficacy and costs of nutritional rehabilitation in muscle-wasted patients with chronic obstructive pulmonary disease in a community-based setting: a prespecified subgroup analysis of the INTERCOM trial. J Am Med Dir Assoc 2010; 11: 179-187
    CrossrefPubMedGoogle Scholar
  • 39 Inostroza M, Valdés O, Tapia G. et al. Effects of eccentric vs concentric cycling training on patients with moderate COPD. Eur J Appl Physiol 2022; 122: 489-502
    CrossrefPubMedGoogle Scholar
  • 40 Gephine S, Frykholm E, Nyberg A. et al. Specific contribution of quadriceps muscle strength, endurance, and power to functional exercise capacity in people with chronic obstructive pulmonary disease: a multicenter study. Phys Ther 2021; 101: pzab052
    CrossrefPubMedGoogle Scholar
  • 41 Guizelini PC, de Aguiar RA, Denadai BS. et al. Effect of resistance training on muscle strength and rate of force development in healthy older adults: A systematic review and meta-analysis. Exp Gerontol 2018; 102: 51-58
    CrossrefPubMedGoogle Scholar
  • 42 Drey M, Zech A, Freiberger E. et al. Effects of strength training versus power training on physical performance in prefrail community-dwelling older adults. Gerontology 2012; 58: 197-204
    CrossrefPubMedGoogle Scholar
  • 43 Henwood TR, Riek S, Taaffe DR. Strength versus muscle power-specific resistance training in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2008; 63: 83-91
    CrossrefPubMedGoogle Scholar
  • 44 Lovell DI, Cuneo R, Gass GC. Can aerobic training improve muscle strength and power in older men?. J Aging Phys Act 2010; 18: 14-26
    CrossrefPubMedGoogle Scholar
  • 45 Sayers SP, Gibson K. A comparison of high-speed power training and traditional slow-speed resistance training in older men and women. J Strength Cond Res 2010; 24: 3369-3380
    CrossrefPubMedGoogle Scholar
  • 46 Herman S, Kiely DK, Leveille S. et al. Upper and lower limb muscle power relationships in mobility-limited older adults. J Gerontol A Biol Sci Med Sci 2005; 60: 476-480
    CrossrefPubMedGoogle Scholar
  • 47 Perry MC, Carville SF, Smith ICH. et al. Strength, power output and symmetry of leg muscles: effect of age and history of falling. Eur J Appl Physiol 2007; 100: 553-561
    CrossrefPubMedGoogle Scholar
  • 48 Valladares-Ide D, Bravo MJ, Carvajal A. et al. Changes in pulmonary and plasma oxidative stress and inflammation following eccentric and concentric cycling in stable COPD patients. Eur J Appl Physiol 2021; 121: 1677-1688
    CrossrefPubMedGoogle Scholar
  • 49 Hopewell S, McDonald S, Clarke MJ. et al. Grey literature in metaanalyses of randomized trials of health care interventions. Cochrane Database Syst Rev 2007; 2007: MR000010
    PubMedGoogle Scholar
  • 50 Deeks JJ, Higgins JP, Altman DG. et al. Analysing data and undertaking meta-analyses. In: Cochrane Handbook for Systematic Reviews of Interventions. John Wiley & Sons, Ltd; 2019: 241-284
    Google Scholar