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Horm Metab Res 2022; 54(03): 194-198
DOI: 10.1055/a-1756-4798
Endocrine Care

Anti-Mullerian Hormone Levels Increase After Bariatric Surgery in Obese Female Patients With and Without Polycystic Ovary Syndrome

Mitat Buyukkaba 
1   Department of Internal Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
,
Seda Turgut 
2   Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
,
Mahmut Muzaffer Ilhan 
3   Department of Endocrinology and Metabolism Diseases, Medipol University, Istanbul, Turkey
,
Iskender Ekinci 
1   Department of Internal Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
,
İlhan Yaylım 
4   Department of Molecular Medicine Istanbul University, Istanbul, Turkey
,
Sakir Umit Zeybek 
4   Department of Molecular Medicine Istanbul University, Istanbul, Turkey
,
Saime Turan 
4   Department of Molecular Medicine Istanbul University, Istanbul, Turkey
,
Ertugrul Tasan 
5   Department of Internal Medicine, Bezmialem Foundation University, Istanbul, Turkey
,
Ozcan Karaman 
5   Department of Internal Medicine, Bezmialem Foundation University, Istanbul, Turkey
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Abstract

This study was aimed to investigate the effect of weight loss by bariatric surgery on the level of anti-Mullerian hormone (AMH) in morbidly obese female patients with or without polycystic ovary syndrome (PCOS). This prospective study includes 70 females, obese, and fertile patients of reproductive age. All patients were evaluated to determine the changes in weight, body mass index (BMI), serum AMH, and other biochemical parameters at the end of six months. The mean levels of the preop and postop AMH were 1.66±0.87 ng/ml and 5.99±1.39 ng/ml in the PCOS group; 1.35±0.76 ng/ml and 6.23±1.47 ng/ml in the non-PCOS group, respectively. The postop AMH levels were significantly higher than the preop levels for both groups (p<0.001). There were significant differences in the level of glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, total cholesterol, hemoglobin A1c, HOMA-IR, insulin between preop and postop 6th month. A negative correlation was found between postop AMH and body weight in all patients (r=–0.337, p=0.031). Postop AMH levels were negatively correlated with postop BMI levels in the non-PCOS patient group (r=–0.408, p=0.043). No significant difference was observed between the PCOS and non-PCOS groups in terms of all the parameters examined. In conclusion, our study suggests that the significantly increased AMH levels by losing weight with bariatric surgery in patients with morbid obesity with and without PCOS may indicate the improvement of fertilization potential. It could be considered when evaluating fertility in patients with morbid obesity.

Key words

infertility - polycystic ovary syndrome - reproductive functions - weight loss


Publikationsverlauf

Eingereicht: 04. Oktober 2021

Angenommen nach Revision: 26. Januar 2022

Artikel online veröffentlicht:
11. März 2022

© 2022. Thieme. All rights reserved.

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