DOI: 10.1055/s-00000131

Synfacts

Issue 12 · Volume 18 · December 2022 DOI: 10.1055/s-012-55731

Synform

A183
Zanda, Matteo: SYNFORM ISSUE 2022/12

Synthesis of Natural Products

z1277
All PDFs of this category
1277
Synthesis of (–)-Bufospirostenin A
1278
Enantioselective Total Synthesis of (+)-Lucidumone
1279
Total Synthesis of (±)-Rameswaralide
1280
Synthesis of (±)-2‑Isocyanoallopupukeanane
1281
Synthesis of (±)-Resiniferatoxin
1282
Total Synthesis of (±)-Ginkgolide C
1283
Total Synthesis of (±)-Saxitoxin

Synthesis of Heterocycles

z1285
All PDFs of this category
1285
Silver-Free Chemoselective O-Benzylation of 2‑Quinolinones
1286
Phase Dependent Tautomerism of 1,3-Thiazine Derivatives
1287
Synthesis of N-Heterocycles via Photoredox Catalysis using Bifunctional Sulfilimines and Alkenes
1288
Skeletal Editing through Nitrogen Atom Insertion to Indoles
1289
Synthesis of Cyclic Enecarbamates through Dehydrogenation
1290
Pd-Catalyzed Synthesis of 2,4-Diarylthiazoles
1291
Synthesis of Nβ‑Substituted 1,2-Diazetidin-3-ones
1292
Metal- and Photocatalyst-Free Switchable Redox Photoexcited Annulation of 2-Nitroarylethanols to NHCs
1293
Oxidative Nucleophilic Substitution of Hydrogen for the Synthesis of Aminated Nitro-Substituted Heteroarenes
1294
One-Pot Multicomponent Protocol To Access Sulfenylimidazo[1,5‑a]pyridines
1295
Synthesis of Aziridines by Reaction of Free Amines with Alkenylthianthrenium Salts
1296
Oxidative Condensation to Access Quinoxalines
1297
Diastereoselective Synthesis of THF Derivatives

Synthesis of Materials and Unnatural Products

z1299
All PDFs of this category
1299
Modular Syntheses of Defined Graphene Nanoribbons
1300
New Synthesis of Mesodiphenylhelianthrene with Its Endoperoxide Formation
1301
Pleiadienes from Palladium-Catalyzed [5+2] Annulation
1302
Magic Graphyne Wheel
1303
Unexpected Cascade Leading to δ-Carboline
1304
Economical Metal-Free Heterocycle Arylation
1305
Ladder Fluorenylidenefluorene Oligomers
1306
Tetracyclic Heteroaromatics from Isocyanide Insertion
1307
Polyselenophenes from Elemental Selenium
1308
Electrophile-Modulated Regiodivergent Syntheses
1309
‘Bottom-Up’ Synthesis of a Semibuckminsterfullerene
1310
Superhelicene with NIR Circularly Polarized Emission

Metals in Synthesis

z1311
All PDFs of this category
1311
Nickel-Catalyzed Enantioselective Multicomponent Reaction of 1,3-Dienes, Aldehydes, and Boronic Acids
1312
Enantio- and Regioselective Hydroalkenylation of Alkenes with Enamides under Iridium Catalysis
1313
Introducing the Magic Methyl: Enantioselective Hydro­methylation of Olefins under Copper Hydride Catalysis
1314
Organolanthanide-Catalyzed α-Borylation of Pyridines: Metal Size Controls Product Distribution
1315
Rhodium-Catalyzed Directed C–H Activation–Insertion Cascade Using Vinylene Carbonate
1316
Asymmetric Hydrogenation of E/Z-Olefin Mixtures by Cobalt Catalysis
1317
Palladium-Catalyzed Annulations Towards π-Extended Coumarins
1318
Palladium-Catalyzed Tandem Aza-Heck Cyclization/C(sp3)–H Functionalization
1319
Iridium-Catalyzed Asymmetric Alkylation of Cyclic Alkenes Using N-Methyl-2-Aminopyridines
1320
Nucleophilic Addition of Benzylic and α-Heteroatom-Substituted Silanes to Aldehydes under Dual Catalysis
1321
Iridium Photocatalyzed Fluoroalkenylation Reaction of Alkyl-Tethered Alkynes
1322
Dual Tungsten/Copper Photocatalysis Enables Direct C(sp3)–H Allylation of Alkanes with Allylic Chlorides
1323
Copper-Mediated Regio- and Diastereoselective Synthesis of Polysubstituted Spiropentanes
1324
Palladium(II)-Catalyzed Domino Cacchi/C–H Activation/Arene Insertion Sequence
1325
Enantioselective Aziridination of Alkenes Utilizing a C4-Symmetric Dirhodium(II) Catalyst
1326
Enantioselective Synthesis of Tetrahydrofurans via a Palladium-Catalyzed [3+2] Cycloaddition
1327
Nickel-Catalyzed Intramolecular Carbo-Oxygenation of Alkenes Using N2O as the Oxygen Source
1328
Direct Arylative Substitution of Homoallylic Alcohols with Arylboroxines under Nickel Catalysis
1329
Iridium-Catalyzed Enantioselective Hydrogenation of Oximes under Lewis and Brønsted Acid Cooperation
1330
Nucleophilic Substitution of Propargylic Alcohols with Arylboronic Acids by Gallium and/or Silver Catalysis
1331
Atroposelective Suzuki–Miyaura Cross-Coupling of ortho-Sulfonyl-Substituted Aryls to Chiral Biaryls
1332
Asymmetric Hydroalkylation of Cyclopropenes with Alkyl Iodides Enabled by Nickel–Hydride Catalysis
1333
Mono- and Dicarboxylation of Unactivated Alkenes Enabled by Photocatalysis
1334
Enantioselective Intermolecular Hydroselenation of Alkenes Using a Cationic Rhodium Catalyst
1335
Access to Halogenated Benzofurans via Au(I)-Catalyzed Cyclization/Hydroarylation of o-Alkynylphenols
1336
Radical Methylation of Primary and Secondary C(sp3)–H Bonds under Copper Catalysis
1337
Molybdenum-Catalyzed Deoxygenative Homo-Coupling of Aromatic Carbonyl Compounds to (E)-Alkenes
1338
Palladium-Catalyzed Silylation via a C–C Bond Cleavage of Unstrained Ketones
1339
1,1,2,2-Tetraborylalkanes via Sequential Diborylation of Terminal Alkynes

Polymer-Supported Synthesis

z1341
All PDFs of this category
1341
Decarboxylative Conjugate Addition of Carboxylic Acids with Alkenes on a Triazine Framework Photocatalyst
1342
Arene Hydrogenation by Cooperative Catalytic Systems of Metal Nanoparticles and Lewis Acids
1343
Photochemical Giese Reaction of Dioxolane and Vinyl Ketones on Graphitic Carbon Nitride
1344
Cycloaddition of CO2 with Epoxides and Knoevenagel Condensation on a Pb10K2 Organic Framework
1345
Photochemical Azide–Alkyne Cycloaddition Catalyzed by a Cuprous Iodide-Based Coordination Polymer
1346
Hydrogenation of Nitriles Promoted by Silica-Supported Nickel Nanoparticles
1347
Aza-Henry Reaction and Oxidation of 1,2,3,4-Tetrahydroisoquinolines on a Copper Nanocatalyst
1348
Iron Chloride Derived Nanoparticles Containing ppm Levels of Ligated Palladium for Negishi Coupling
1349
Synthesis of Benzo[a]pyrano[2,3-c]phenazine Derivatives on CuO Quantum Dots
1350
Zinc-Catalyzed Photochemical Dehydrogenative Cycloaddition and Carbonyl Cyanosilylation
1351
Reductive Annulation of Quinolines and Enones on an Ir Catalyst Supported on Hierarchically Porous Zirconia

Organo- and Biocatalysis

z1353
All PDFs of this category
1353
Halogen-Atom and Group Transfer Reactivity through Quantum Mechanical Tunneling
1354
Biocatalytic Cascade Approach Permits Rapid Access to Enantioenriched 1,2-Amino Alcohols
1355
Ene-Reductase Permits Cross-Electrophile Coupling of α-Chloro Carbonyls with α-Aryl Nitroalkanes
1356
Photocatalytic Amidylimination of Terminal Alkenes
1357
Noncovalent Interactions Tame Radical Intermediates
1358
Organophotocatalytic Generation of Alkyl Radicals by C–C Bond Cleavage and Radical Conjugate Addition
1359
Direct Photocatalytic Reductive Benzoylation of Olefins with Benzoic Acids
1360
Electrophotocatalytic Formation of Regioisomeric Oxazolines from Aryl Olefins
1361
Hydrosilane Organocatalyst Permits Broadly Applicable Amidation under Mild Conditions
1362
NHC-Catalyzed Atroposelective Synthesis of 1,3-Oxazepine-Containing Bridged Biaryls
1363
Thioxanthone/TfOH-Photocatalyzed Xylene-Mediated Hydrogenation of α,β-Unsaturated Carbonyls
1364
Skeletal Editing of Aryl Azides toward Aminopyridines through Nitrogen Insertion and Carbon Deletion

Innovative Drug Discovery and Development

z1365
All PDFs of this category
1365
RapaBlock, a Novel Drug that Prevents the On-Target – Off-Tissue Effects of mTOR Inhibition
1366
Small Molecule Inhibitors of the YAP-TEAD Interaction
1367
The Fabulous Fabimycin
1368
From Data to Prediction: Thermal Risk Analysis of Cyclic Sulfamidates
1369
Discovery of a Potent Importin Inhibitor for Cancer Treatment
1370
Nanogels with Cyanine Cross-Linker Enable Light-Mediated Control of Drug Delivery and Release
1371
Discovery of a Next-Generation Inhibitor of HIV-1 Maturation Based on Betulinic Acid
1372
Total Synthesis of Elongation Factor Antagonist SR-A3
1373
Poxin-Resistant cGAMP-Derivatives Halt Viral Escape
1374
Janustatins – Cytotoxic Polyketide Alkaloids
1375
Efficient Synthesis of SM-406
1376
A Versatile Approach Towards Novel Pleuromutilin Antibiotics
1377
Synthesis of Coagulation Factor Xa Inhibitor Apixaban

Peptide Chemistry

z1379
All PDFs of this category
1379
Domino Reaction to Form Polycyclic Spiro Compounds Containing Amino Acid Residues
1380
Nickel/Iridium-Catalyzed Cross-Coupling of Amino Acid Chlorides with C(sp3)–H Hydrocarbons
1381
Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation
1382
Microwave-Induced Inverse Peptide Synthesis
1383
Copper-Catalyzed Alkynylation of Azapeptides
1384
Zinc-Catalyzed Desymmetric Reduction To Form Hydroxylated Tetrasubstituted Amino Acids
1385
Electrochemical Tandem Azidation/Heterocyclization of Tryptophan-Containing Peptides
1386
Synthesis of N-Allyl Amino Acids and Peptides

Flow Chemistry

z1387
All PDFs of this category
1387
Development of Continuous Flow System for β-Keto Ester Synthesis
1388
Synthesis of Unsymmetrical Biaryls via Photoinduced Arylation of Chloroarenes in Flow