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Synfacts 2022; 18(12): 1381
DOI: 10.1055/s-0042-1752352
Peptide Chemistry

Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation

Contributor(s):
Hisashi Yamamoto
,
An Wu
Su J, Mo J.-N, Chen X, Umanzor A, Zhang Z, Houk KN, Zhao J. * Dalian University of Technology, P.R. of China
Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow.

Angew. Chem. Int. Ed. 2022;
61: e202112668
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Key words

peptide bond formation - photoredox catalysis - cobaloxime catalysis - iridium catalysis - phosphines - flow reaction

Significance

Peptide bond formation is important in drug discovery and medicinal chemistry. The authors have developed a photoredox cobaloxime/iridium complex-catalyzed reaction to form peptide bonds under mild conditions with triphenylphosphine as a gentle reductant.


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Comment

Various examples of peptides, including dipeptides, tripeptides, and tetrapeptides were prepared in moderate to good yields under blue LED irradiation.


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Publication History

Article published online:
17 November 2022

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