DOI: 10.1055/s-00000131

Synfacts

Issue 11 · Volume 16 · November 2020 DOI: 10.1055/s-010-49640

Synform

A153
Zanda, Matteo: SYNFORM ISSUE 2020/11

Synthesis of Natural Products and Potential Drugs

z1257
All PDFs of this category
1257
Total Synthesis of (±)-Aspidofractinine
1258
Synthesis of Glecaprevir. Part 1
1259
Synthesis of Glecaprevir. Part 2
1260
Synthesis of BMS-986251
1261
Synthesis of (±)-Walsucochinoids M and N
1262
Synthesis of Cephanolide A
1263
Synthesis of (–)-Daphnezomines A and B
1264
Synthesis of Cebranopadol
1265
Synthesis of (+)-Phomactin A
1266
Synthesis of TAK-828F
1267
Synthesis of MIDD0301
1268
Synthesis of Tenofovir
1269
Synthesis of LSZ102
1270
Synthesis of an Arginase Inhibitor
1271
Synthesis of (±)-Kopsinitarine E
1272
Total Synthesis of (±)-Ginkgolide B
1273
Synthesis of Brensocatib

Synthesis of Heterocycles

z1275
All PDFs of this category
1275
Isolation and Structural Characterization of Three New Benzazepines
1276
Chiral Hemiketal Formation by Organocatalytic Desymmetrization of gem-Diols
1277
Synthesis of Spirocyclic Pyrrolidones from Diazobutyrolactams
1278
Scalable Synthesis of Functionalized gem-Difluorocyclopropanes
1279
C–H Bond Functionalization of Alicyclic Amines
1280
Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts
1281
Minisci Reaction of N-Hetarenes with Cyclopropanols as the Radical Source
1282
Synthesis and Derivatization of N-Trifluoromethylated Indoles
1283
Mild Regioselective Halogenation of Anilines, Anilides, and Indoles
1284
Pd-Catalyzed Asymmetric [8+2]-Dipolar Cycloadditions: Synthesis of Ten-Membered Ring Heterocycles
1285
Cobalt(III)-Catalyzed Synthesis of Isoquinolinones and Pyridinones by Annulative Vinylene Transfer
1286
Chiral N,O-Acetals by Asymmetric Hydrogenation of Cationic Intermediates
1287
Metal-Free [5+1]-Cycloaddition Route to Pyrazine 1-Oxides and Pyrazines
1288
Two-Step Synthesis of Functionalized Benzoxazoles

Synthesis of Materials and Unnatural Products

z1289
All PDFs of this category
1289
A Missing Member of the Cycloarene Family: Quintulene
1290
Amide–Alkene Isosterism: Synthesis of Olefin-Containing Foldamers
1291
Getting the SuFEx Right for Sulfamides
1292
Reductively Aminate, Reuse, Recycle
1293
Insert COins Here
1294
Oxygen Chelation Makes it Exclusive: Fluorene-Based Spirocycles via Aryl Halide Cross-Coupling
1295
Oxidative Dealkylation Strategy toward Functionalized Phenalenones
1296
Synthesis of as-Indacenoterrylene, a C70 Fragment with NIR absorption
1297
Air- and Moisture-Tolerant Synthesis of Catechol Boronic Esters
1298
Suzuki–Miyaura to the Rescue! Expanding the Scope for Tetraarylethylene Synthesis
1299
Sticking Together: Fused Porphyrins Deliver Protection against Photodegradation to Pentacenes
1300
The Coronation of Naphthalene Diimides: π-Extended Helicenes by Oxidative Cyclization

Metals in Synthesis

z1301
All PDFs of this category
1301
Asymmetric γ-Borylation of Aliphatic Amides and Esters
1302
Gold-Catalyzed Carbene Transfer towards the C–H Functionalization of N-Heterocycles
1303
Dynamic Kinetic Resolution Strategy for the Asymmetric Nickel-Catalyzed Capture of Transient Cyclic Allenes
1304
Visible-Light-Promoted Copper-Catalyzed Difunctionalization of Alkenes with Iodoform
1305
Chlorocarbonylation of Aryl (Pseudo)Halides via Pd-Catalysis
1306
Synthesis of δ- and ε-Lactones Through γ-C(sp3)–H Activation of β-Disubstituted Carboxylic Acids
1307
Ruthenium-Catalyzed Synthesis of Cyclic Tetrasubstituted Olefins
1308
Synthesis of Cyclopropanes by Double C–H Activation
1309
Synthesis of C-Aryl Glycosides by Catellani Reaction
1310
Intermolecular Pd-Catalyzed Carbofunctionalization of Internal Alkynes with trans-Selectivity
1311
Rh-Catalyzed Three-Component Synthesis of α,α,α-Trisubstituted Esters by C(sp2)–C(sp3) Bond Cleavage
1312
Photocontrolled Hydroboration of α,β-Unsaturated Ketones
1313
gem-Hydrogenation of Internal Alkynes by Grubbs Metathesis
1314
Cobalt-Catalyzed Dienylation of Quinoline-N-Oxides: C8-Selective Alkenylation
1315
Synthesis of Benzylic Ketones through Electrochemical Oxidation of Aryl Alkenes
1316
Nickel-Catalyzed Hydroarylation of Alkenes
1317
Synthesis of Trisubstituted Hydroxylamines
1318
Regioselective Alkyne Cyclotrimerization Enabled by Hemilability of Salen Ligand
1319
Asymmetric Allylation of Terminal Alkynes by Rhodium/Copper Catalysis
1320
Switching Reactivity: Bromoalkynylation of Alkynes and Hydroalkynylation of Haloalkynes via Gold Catalysis
1321
Palladium-Catalyzed Stereoselective β-Arylation of Acyclic Aliphatic Amides
1322
Regio- and Enantioselective Synthesis of Chiral Allylic Sulfones
1323
Sulfinyl Nitrene Based Synthesis of Sulfoximines and Sulfonimidamides
1324
Asymmetric Synthesis of α‑Alkylated Pyrrolidinones from Homoallylic Carbamoyl Chlorides
1325
Carbon Dioxide and Ammonia as Cyanide Source in Nickel-Catalyzed Reductive Cyanation of Aryl Chlorides
1326
Design of a Catalyst Suitable for Aryl Aminations at Room Temperature
1327
Titanium-Catalyzed Asymmetric Pauson–Khand Type Reaction
1328
Synthesis of Chiral Alkenylphosphine Oxides

Polymer-Supported Synthesis

z1329
All PDFs of this category
1329
A Single-Atom Cobalt Catalyst Supported on SBA-15 for Hydrodeoxygenation and Hydrogenation
1330
Enantioselective Addition of Dialkylzinc to Aldehydes on a Heterogeneous Magnetic Nanoparticle Catalyst
1331
Photocatalytic C–C Bond Cleavage of Lignin Model Compounds on Silver-Doped Cadmium Sulfide NPs
1332
Oxidative Amine Coupling and Thioamide Cyclization with a Photocatalytic Covalent Organic Framework
1333
Hydrodeoxygenation of 4-Hydroxyacetophenones on Immobilized Fe–Ru Bimetallic Nanoparticles
1334
Synthesis of 2-Amino-3-cyano-4H-chromenes on Graphene Oxide-Supported Piperazine
1335
Oxidation of Sugar Alcohols Catalyzed by a Polymeric N-Heterocyclic Carbene–Iridium Complex
1336
Parts Per Million Pd/C-Catalyzed Reductive Aminations in an Aqueous Micellar Medium
1337
Aerobic C–C Bond Cleavage of Vicinal Diols Promoted by Heterogeneous Carbon Nitride CN620
1338
Graphite-Supported Cu–Ag Nanoparticle Catalysts for Oxidation and Chan–Lam Coupling
1339
Cyclopropanation of Olefines Catalyzed N-doped Graphene-Supported Iron Nanoparticles

Organo- and Biocatalysis

z1341
All PDFs of this category
1341
Chemoenzymatic Dynamic Kinetic Resolution at Normally Static Stereogenic Centers
1342
TEMPO-Catalyzed Di- and Trifluoromethoxylation of Arenes
1343
Enzyme-Dependent Oxygenation Permits Highly Selective Synthesis of Diterpenes
1344
Synthesis of Complex Isoprenoid Scaffolds by a Monodomain Class II Terpene Cyclase
1345
Thiourea-Stabilized Carboxylic Acids Permit [4+2] Cycloadditions of Acetals and (Bis)homoallylic Alcohols
1346
Organocatalytic Oxygen Reduction: Dicarbenium Ions as Catalysts
1347
Organic Photoredox Catalyzed Deoxyfluorination of Electron-Rich Arenes
1348
A Dual Organocatalytic Approach to Chiral S-Heterocycles
1349
Radical N-Heterocyclic Carbene Catalysis for the Synthesis of Hindered Alkyl Ketones from Aldehydes
1350
Chiral Imidazole-Catalyzed Synthesis of Remdesivir through Dynamic Kinetic Resolution
1351
Purely Organocatalytic C–H Insertion and Cyclopropanation Reactions with α-Diazo Esters

Chemistry in Medicine and Biology

z1353
All PDFs of this category
1353
A PROTAC for KRAS G12C Degradation
1354
PEARL-seq: A Workflow for Analyzing Small Molecule–RNA Interactions
1355
Macropinocytosis is Key to Peptidomimetic Uptake in Cancer Cells
1356
Natural Products in Drug Discovery
1357
Copper Sensing by Electrophile Activation
1358
Introducing Phosphorylation-Inducing Chimeric Small Molecules (PHICS)
1359
Non-nucleotide cGAMP Mimetics with Powerful Antitumor Activity
1360
Total Synthetic Lankacidin Antibiotics
1361
A Mild and General Synthesis of Substituted Anilines
1362
A Tool to Observe Cellular Apposition
1363
One, Two, Three – Nucleosides
1364
Bioluminescence Seeing Red
1365
The First Contraceptive
1366
Pumping and Probing for the Optimal Dienophile

Peptide Chemistry

z1367
All PDFs of this category
1367
Palladium-Catalyzed C(sp3)–H Arylation of Peptides Assisted by Unmodified Asparagine
1368
Ni-Catalyzed Decarboxylative Borylation toward α-Aminoboronates and Peptide-Boronic Acids
1369
Synthesis of Peptides Containing α,α-Difluoro-β-amino Acids from α,α-Difluoro Lactams
1370
Transamination for Synthesis of Unprotected Glycine Derivatives
1371
Modification of Tryptophan by Using Triarylbismuthines and Copper(II) Acetate
1372
Photoredox-Catalyzed Synthesis of α-Amino Acid Derivatives
1373
Chiral Phosphoric Acid-Catalyzed Synthesis of α-Amino Acid Derivatives
1374
Cooperative Catalysis for the Synthesis of β-Prolines
1375
Synthesis of Cyclic Peptides by Palladium-Catalyzed Intramolecular C(sp3)–H Arylation
1376
Photoinduced α-C(sp3)–H Functionalization of Amino Acids and Peptides
1377
Dipeptide Synthesis from S-2-Formyl-4-Nitrophenyl Thioesters and Amino Acid Salts
1378
Decarboxylative Carbonylation of α-Amino Acids

Flow Chemistry

z1379
All PDFs of this category
1379
Asymmetric C–H Functionalization in Flow by an Immobilized Rhodium Carboxylate Catalyst
1380
Iodine–Lithium Exchange Reaction of Benzylic Iodides
1381
Iridium-Photocatalyzed Formation of Tetrahydroquinolines