DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 15 · March 2019 DOI: 10.1055/s-009-42509

Synform

A32
Zanda, Matteo: SYNFORM ISSUE 2019/03

Synthesis of Natural Products and Potential Drugs

z0215
All PDFs of this category
0215
Synthesis of PF-06650833
0216
Synthesis of (–)-Merochlorin A
0217
Total Synthesis of (–)-Sinulariadiolide
0218
Total Syntheses of (–)-Jorunnamycin A and (–)-Jorumycin
0219
Asymmetric Synthesis of a Carbapenem Intermediate
0220
Synthesis of the Reported Structure of (+)-Stresgenin B
0221
Concise Four-Step Total Synthesis of (±)-Carpanone
0222
Synthesis of a GPR40 Superagonist
0223
Synthesis of (+)-Hypercalin C
0224
Syntheses of Herquline B and C

Synthesis of Heterocycles

z0225
All PDFs of this category
0225
Synthesis of Spiroazetidinimine Oxindoles
0226
Synthesis of Benzodithiazines by an ortho-Metalation–Oxidative Cyclization Route
0227
Visible-Light-Promoted Decarboxylative C–H Adamantylation of Azoles
0228
Palladium-Catalyzed Synthesis of Indolin-2-ones and Dihydroquinolin-2-ones
0229
Syntheses of Highly Substituted Dihydropyridine Derivatives from Hantzsch Esters
0230
Chemodivergent Approach to Lactones and Lactams
0231
Synthesis of Spirobarbiturate–Cyclopropanes
0232
Cycloaddition Reaction of Alkynyltrifluoroborates with Azetidinones and Oxetanones
0233
Synthesis of N-Heterocyclic Carbene–Boralactone Complexes from Alkenylboranes
0234
A Short Route to 3-Fluoroalkyl-5-Pyrazolecarboxylates
0235
Visible-Light-Mediated Cyclopropane Construction
0236
Reaction of 2-Mercaptopyridine with Nitroallylic Acetates to Form Indolizines
0237
Direct Carbamoylation of Heterocycles through a Minisci Reaction
0238
Iridium-Catalyzed Synthesis of Fluorinated Benzothiazoles
0239
6-exo-dig Iodocyclization Route to Dihydro-1,3-oxazines

Synthesis of Materials and Unnatural Products

z0241
All PDFs of this category
0241
Rhodium Cross-Stitching Sews Up Dibenzofulvalenes
0242
Stitching Together New Helicenes
0243
Heat On, Heat Off: A Synthesis of Polyacetylene Revisited
0244
Self-Sorted Cryptands Prepared by Dynamic Covalent Chemistry
0245
Nickel-Catalyzed Migita Reaction of Chloro(hetero)arenes with Thiolates
0246
Porphyrin-Aggregation Suppressed by Surrounding it with an Alkyl Ring
0247
Synthesis of Arene-Fused Thioxanthenes from Thiomethylnaphthalene
0248
A Bit of Alkyne Makes Seven Better than Five
0249
A Clickable Hexavalent Basket with a Dual Cavity
0250
Curvy Corannulenes
0251
A Tale of Two Antiaromaticities
0252
Acrylamide Surprise: Where’d the Triazole Go?

Metals in Synthesis

z0253
All PDFs of this category
0253
The Sharpless Epoxidation
0254
Palladium-Catalyzed Alkylations Induced by Visible Light
0255
Asymmetric 1,2-Dicarbofunctionalization of Alkenes with Copper/Chiral Phosphoric Acid System
0256
Directed meta-C–H Functionalization with Unactivated Alkynes with Rhodium(III) Catalyst
0257
Water-Stable Cross-Couplings between Organolithiums and Aryl Halides
0258
Nickel-Catalyzed Asymmetric Reductive Amination of Sulfonamides
0259
The First Enantioselective Rhodium-Catalyzed 1,4-Addition
0260
Lewis-Acid-Driven N- or O-Cyclization of Urea-Tethered Cyclobuta[b]indolines
0261
Titanium-Catalyzed Regioselective Pyrrole Synthesis Using Directing Group Effects
0262
Stereoselective Synthesis of Cyclobutenes via Nickel Catalysis
0263
Asymmetric Copper-Catalyzed Addition of α-Fluoronitriles to Imines
0264
Palladium-Catalyzed Cross-Coupling of gem-Bis(boronates) with Aryl Halides
0265
Anilines from Activated Benzoic Acids by Metal-Mediated Decarboxylative Amination
0266
Ring-Fused Pyridinium Compounds from Rhodium-Catalyzed Multicomponent Reactions
0267
Radical Branch-Selective Addition to Imines and Aldehydes
0268
Copper-Catalyzed 1,4-Protoboration of Dienylboronates
0269
Photoinduced Cobalt-Catalyzed [4+2] Cycloaddition Reactions
0270
Photocatalytic Amination of Arenes
0271
Radical Relay Heck Reaction
0272
Synthesis of Five-Membered Heterocycles Starting from Cyclopropanes
0273
Cross-Electrophile Csp3–Csp3 Coupling of Aliphatic Bromides
0274
Cobalt-Catalyzed Radical–Polar Crossover Reactions of Allylic Alcohols
0275
Iridium-Catalyzed Enantioselective Bidirectional Reductive Coupling
0276
A New Fluoroalkylation–Borylation of Alkynes
0277
Fe/Ti Cocatalyzed Aryl–Aryl Cross-Coupling
0278
Homolytic C–O Bond Cleavage and Trapping via a Zinc/Nickel System
0279
Nickel-Catalyzed Cross-Coupling of Zinc Pivalates with Nonaflates and Triflates
0280
Copper-Catalyzed Regioselective Functionalization of Naphthylamines
0281
Enantioselective Ring Opening/Cross-Coupling or Cyclopropanation of Cyclobutanones

Polymer-Supported Synthesis

z0283
All PDFs of this category
0283
Formal Hydroacylation of Alkynes on Mg3Al–CO3-Layered Double Hydroxide
0284
Dehydrogenative Coupling of Tetrahydroisoquinolines and Nitroalkanes
0285
Suzuki–Miyaura Reaction on Hybrid Hydrogel-Supported Pd Nanoparticles
0286
A Recyclable Layered Double-Hydroxide-Supported Fe3O4–Rose Bengal Photocatalyst
0287
Au-Catalyzed Oxidative Coupling of Propargylic Acetates with Arylboronic Acids
0288
Synthesis of Pyrimidines from Alcohols and Amidines on Pt/C Nanoparticles
0289
Aerobic Benzylic and Allylic Oxidations on Pd–Cu Bimetallic Nanoparticles
0290
CdS Nanoparticle Photocatalyzed C–H Functionalization
0291
Pd-Catalyzed Carbonylative Synthesis of Ureas with CO Generated in situ in H2O
0292
Oxidative Esterification of α-Hydroxy Ketones on a Bimetallic Cu–Mn Catalyst

Organo- and Biocatalysis

z0293
All PDFs of this category
0293
Catalytic Deracemization of Allenes
0294
Iodine-Catalyzed Carbonyl–Olefin Metathesis
0295
The Morita–Baylis–Hillman Reaction
0296
Asymmetric Synthesis of 2-Pyrazolines by a Catalytic Aza-Michael Addition
0297
Metal-Free Transfer Hydroiodination of Allenes and Alkynes
0298
Chiral Phosphoric Acid Catalyzed [4+2] Cycloaddition toward Griffipavixanthone
0299
Enantioselective Dearomatization of Pyrylium Derivatives
0300
Chiral Phosphoric Acid Catalyzed Allylic Dearomatization of α- and β-Naphthols
0301
Enantioselective Construction of Vicinal Diaxial Styrenes and Multiaxis Systems
0302
Peroxygenase-Catalyzed Hydroxylation of Ethylbenzene
0303
Baeyer–Villiger Oxidation Catalyzed by a Peptide-Based Phosphoric Acid

Chemistry in Medicine and Biology

z0305
All PDFs of this category
0305
A New Class of Stimulator of Interferon Genes Receptor Agonists
0306
Design and Synthesis of a Potent Spongistatin 1 Analogue
0307
Organophotoredox-Catalyzed Sulfoximidation of Electron-Rich Arenes
0308
A Fluorinated Carbocyclic Nucleoside with Anti-HBV Activity
0309
Synthesis, Configuration, and Activity of an Anti-inflammatory Resolving Agonist
0310
Synthesis and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues
0311
A Nimbolide-Derived PROTAC
0312
Copper-Catalyzed ortho-Radiofluorination of Aromatic C–H Bonds
0313
Protecting-Group Free Synthesis of (–)-Δ8-THC Derivatives
0314
Photoswitchable Gramicidin S Derived β‑Hairpin Peptides
0315
Near-IR Polymethine Fluorophores Absorbing Beyond 1000 nm
0316
An Improved Photocaged Puromycin

Peptide Chemistry

z0317
All PDFs of this category
0317
Synthesis of Cyclophane-Braced Peptide Macrocycles
0318
Preparation of 2-Aminocyclopropanecarboxylic Acid-Derived Peptides
0319
Palladium-Catalyzed C–H Functionalization of N-Methyl Amino Acids
0320
Cyclocarbonylation of Aromatic α-Amino Acids Promoted by Potassium Iodide
0321
Cobalt-Catalyzed C–H Alkylation of Tryptophan Derivatives
0322
Palladium-Catalyzed Olefination of Phenylalanine Residues in Peptides
0323
Unnatural Amino Acids and Peptides Synthesis by Photoredox Catalysis
0324
Palladium-Catalyzed Thioglycoconjugation of Iodoaryl Peptides and Amino Acids
0325
BINOL-Catalyzed Propargyl- or Allylboration of Hydrazono Esters
0326
Chemical Ligation of Unprotected Peptide Segments

Flow Chemistry

z0327
All PDFs of this category
0327
Flow Synthesis of 3-(Mesitylthio)-1H-1,2,4-triazole
0328
Flow Production of Anhydrous tert-Butyl Hydroperoxide
0329
Homologation of Ketones and Aryl Aldehydes in Flow
0330
A Laser-Driven Flow-Chemistry Platform for Scaling Photochemical Reactions
0331
Heterogenous Platinum-Catalyzed Direct Reductive Amination