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Synfacts 2019; 15(03): 0283
DOI: 10.1055/s-0037-1611209
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Formal Hydroacylation of Alkynes on Mg3Al–CO3-Layered Double Hydroxide

Contributor(s):
Yasuhiro Uozumi
,
Kazuki Tani
Yatabe T, Mizuno N, Yamaguchi K. * The University of Tokyo, Japan
Transition-Metal-Free Catalytic Formal Hydroacylation of Terminal Alkynes.

ACS Catal. 2018;
8: 11564-11569
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Further Information

Publication History

Publication Date:
15 February 2019 (online)

 
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Key words

transition-metal-free reaction - layered double hydroxide - hydroacylation - alkynes - aldehydes

Significance

Mg3Al–CO3-layered double hydroxide (Mg3Al–CO3 LDH) catalyzed the formal hydroacylation of terminal arylalkynes with aromatic aldehydes under argon to give the corresponding diaryl α,β-unsaturated ketones in up to 85% yield (24 examples).


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Comment

In the reaction of phenylacetylene with p-anisaldehyde, Mg3Al–CO3 LDH was recovered and reused three times with a slight loss of its catalytic activity (fresh: 91% yield; third reuse: 73% yield).


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