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Hamostaseologie 2013; 33(01): 17-20
DOI: 10.5482/HAMO-13-01-0002
Review
Schattauer GmbH

MicroRNAs in platelet physiology and pathology

Micro-RNA, Physiologie und Pathologie der Thrombozyten
S. Dangwal
1   Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany
,
T. Thum
1   Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany
› Author Affiliations
Further Information

Publication History

Received: 07 January 2013

Accepted in revised form: 17 January 2013

Publication Date:
28 December 2017 (online)

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Summary

MicroRNAs (miRNAs), highly conserved, short (approx. 22 nucleotides) non-coding RNAs, exhibit a fine-tune control over gene expression by complementary sequence binding and translational repression of protein coding mRNA transcripts. Recently, the role of miRNAs has been increasingly investigated in various physiological or pathophysiological events.

Circulating platelets are crucial for coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. Anucleate platelets lack genomic DNA but inherit diverse array of functional coding or non-coding RNAs and translational machinery from their parent cells – mega-karyocytes enabling activated platelets to synthesize proteins which suggests the possibility of post transcriptional gene regulation in platelets. Expression of functionally active miRNAs in platelets changes during platelet activation indicating a role in platelet biology.

Here, we present a review on recently identified platelet miRNAs and their role in platelet physiology that is essential for maintaining haemostasis.

Zusammenfassung

MicroRNAs (miRNAs) sind evolutionär hochkonservierte kurze (etwa 20 Nukleotide) nicht kodierende RNA Moleküle, die eine Kontrolle der Genexpression durch Bindung an komplementäre mRNA-Sequenzen und translationale Repression von Proteinkodierenden mRNA-Transkripten bewirken. MiRNAs sind an vielen physiologischen und pathophysiologischen Vorgängen des Körpers beteiligt.

Zirkulierende Thrombozyten sind essenziell für die Balance der Blutgerinnung und auch bedeutend für die vaskuläre Integrität. Sie sind ebenso bei atherosklerotischen wie auch bei thrombotischen Erkrankungen involviert. Anuklären Thrombozyten fehlt genomische DNA, aber sie besitzen eine Anzahl funktionell kodierender aber auch nicht kodierender RNA-Moleküle. Des Weiteren besitzen Thrombozyten eine funktionstüchtige translationale Maschinerie, die es ihnen erlaubt, Proteine zu synthetisieren – Prozesse, die wiederum über miRNAs reguliert werden.

Die Bedeutung von nicht kodierenden micro-RNAs in der Regulation der Thrombozytenfunktion ist daher Gegenstand dieses Übersichtsartikels.

Keywords

MicroRNAs

Schlüsselwörter

MicroRNAs
 

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