Extraction of Cochlear Non-linearities with the Bispectral Analysis

E. Chiaramello; S. Moriconi; G. Tognola

doi:10.3414/ME14-01-0004

Methods of Information in Medicine, Table of Contents

Methods Inf Med 2014; 53(05): 364-370
DOI: 10.3414/ME14-01-0004

Original Articles

Schattauer GmbH

Extraction of Cochlear Non-linearities with the Bispectral Analysis

An Application to TEOAEs in Styrene-exposed Workers

E. Chiaramello

¹CNR IEIIT – National Research Council of Italy Institute of Electronics, Computer and Telecommunication Engineering, Milan, Italy

,

S. Moriconi

¹CNR IEIIT – National Research Council of Italy Institute of Electronics, Computer and Telecommunication Engineering, Milan, Italy

,

G. Tognola

¹CNR IEIIT – National Research Council of Italy Institute of Electronics, Computer and Telecommunication Engineering, Milan, Italy

› Author Affiliations

Abstract

Summary

Objectives: Transient Otoacoustic Emission (TEOAEs) are low intensity sounds generated by active mechanisms in the cochlea and elicited by broadband and short acoustic stimuli. TEOAEs are a quick, non-invasive, and very reliable measure to objectively assess the peripheral auditory system. In the current study, we present a recent technique to extract and evaluate non-linearities in TEOAEs, and apply it for the preliminary analysis of TEOAE recordings of a group of worker of a fiberglass manufacturing facility exposed to styrene solvent.

Methods: Bispectral analysis was applied to TEOAEs to extract the quadratic frequency couplings (QFCs) in TEOAEs. Amplitude of QFCs was calculated in a group of 7 styrene-exposed workers (14 ears) and compared with normative results obtained on normal hearing young adults.

Results: Difference in amplitude of QFCs were found between workers and controls. In workers, TEOAE non-linear components were found in the 1.5 – 4 kHz frequency range, whereas in control subjects they were found in a lower frequency region, ranging from 1 to 3 kHz.

Conclusion: The amplitude of QFCs highlighted differences in TEOAEs recorded among workers and controls.

Keywords

Bispectral analysis - cochlear non-linearities - otoacoustic emissions - styrene-exposure

Full Text

References

References
1 Kemp DT. Otoacoustic emissions, their origin in cochlear function, and use. British Medicine Bulletin 2002; 63: 223-241.
2 Probst R, Lonsbury-Martin BL, Martin GK. A review of otoacoustic emissions. J Acoust Soc Am 1991; 89 (05) 2027-2067.
3 Robinette MS, Glattke TJ. Otoacoustic Emissions: Clinical Applications. New York: Thieme; 1997: 4
4 Bray P, Kemp DT. An advanced cochlear echo technique suitable for infant screening. Br J Audiol 1987; 21 (03) 191-204.
5 Bhagat S, Bass J, Qaddoumi I, Brennan I, Wilson M, Wu J, Galindo CR, Paglialonga A, Tognola G. Time-frequency analysis of transient-evoked otoacoustic emissions in children exposed to Carboplatin chemotherapy. Audiol Neurootol 2013; 18 (02) 71-82.
6 Tognola G, Grandori F, Avan P, Ravazzani P, Bonfils P. Frequency-specific information from click evoked otoacoustic emissions in noise induced hearing loss. Hear Res 1999; 38 (05) 243-250.
7 Sisto R, Cerini L, Gatto MP, Gherardi M, Gordiani A, Sanjust F. Otoacoustic emission sensitivity to exposure to styrene and noise. J Acoust Soc Am 2013; 134 (05) 3739-3748.
8 Paglialonga A, Barozzi S, Brambilla D, Soi D, Cesarani A, Gagliardi C, Comiotto E, Spreafico E, Tognola G. Cochlear active mechanisms in young normal-hearing subjects affected by Williams syndrome: time-frequency analysis of otoacoustic emissions. Hear Res 2011; 272 (1-2) 157-167.
9 Paglialonga A, Fiocchi S, Del Bo L, Ravazzani P, Tognola G. Quantitative analysis of cochlear active mechanisms in tinnitus subjects with normal hearing sensitivity: time-frequency analysis of transient evoked otoacoustic emissions and contralateral suppression. Auris Nasus Larynx 2011; 38 (01) 33-40.
10 Chua KC, Chandran V, Acharya RU, Lim CM. Application of higher order statistics/spectra in biomedical signals-a review. Med Eng Phys 2010; 32 (07) 679-689.
11 Schack B, Rappelsberger P, Vath N, Weiss S, Möller E, Grießbach G, Witte H. EEG frequency and phase coupling during human information processing. Methods Archive 2001; 40 (02) 106-111.
12 Schwab K, Eiselt M, Schelenz C, Witte H. Time-variant parametric estimation of transient Quadratic phase couplings during electroencephalographic burst activity. Methods Inf Med 2005; 44 (03) 374-383.
13 Khadra L. Al-Fahoum AS, Binajjaj S. A quantitative analysis approach for cardiac arrhythmia classification using higher order spectral techniques. IEEE Transactions on Biomedical Engineering 2005; 52 (11) 1840-1845.
14 Shera CA. Mechanisms of mammalian otoacoustic emission and their implications for the clinical utility of otoacoustic emissions. Ear Hear 2004; 25 (02) 86-97.
15 Marchesi S, Tognola G, Paglialonga A. The bispectral approach for the analysis on non-linear cochlear active mechanisms in Transient Evoked Otoacoustic Emissions. IEEE Trans Biomed Circuits Syst 2013; 7 (04) 401-413.
16 Tognola G, Paglialonga A, Chiaramello E. Bispectral analysis of Transient Evoked Otoacoustic Emissions to study factors influencing cochlear non-linearities: normative data in young adults. IEEE Sensors Journal 2013; 13 (09) 3249-3254.
17 Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Wesolowski W, Pawlaczyk-Luszczynska M. Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise. J Occup Environ Med 2003; 4: 15-24.
18 Johnson AC, Morata TC, Lindblad AC, Nylon PR, Svensson E, Krieg E, Aksentijevic A, Prasher D. Audiological findings in workers exposed to styrene alone or in concert with noise. Noise Health 2006; 8: 45-57.
19 Morata TC, Sliwinska-Kowalska M, Johnson AC, Starck J, Pawlas K, Zamyslowska-Szmytke E, Nylen P, Toppila E, Krieg E, Pawlas N, Prasher D. A multicenter study on the audiometric findings of styrene-exposed workers. Int J Audiol 2011; 50: 652-660.
20 Zhou G, Giannakis GB. Polyspectra analysis of mixed process and coupled harmonics. IEEE Trans Inf Theory 1996; 42 (03) 943-958.
21 Nikias CL, Raghuveer MR. Bispectrum estimation: a digital signal processing frame work. Proc IEEE 1987; 75 (07) 869-891.
22 Sulkowsky WJ, Kowalska S, Matyja W, Guzek W, Wesolwski W, Szymczak W, Kostrzewski P. Effects of occupational exposure to a mixture of solvents on the inner ear: A field study. Int J Occup Med Environ Health 2002; 15: 247-256.
23 Triebig G, Bruckner T, Seeber A. Occupational styrene exposure and hearing loss: a cohort study with repeated measurements. Int Arch Occup Environ Health 2009; 82: 463-480.