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Tierarztl Prax Ausg G Grosstiere Nutztiere 2017; 45(03): 182-186
DOI: 10.15653/TPG-160480
Case Report
Schattauer GmbH

Ocular involvement of multicentric malignant B-cell lymphoma in a ewe

A case reportOkuläre Beteiligung eines multizentrischen malignen B-Zell-Lymphoms bei einem SchafEin Fallbericht
James O. Rushton
1   Department of Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria
,
Denise Thaller
2   Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria
,
Reinhild Krametter-Froetscher
3   Department for Farm Animals and Veterinary Public Health, University Clinic of Ruminants, University of Veterinary Medicine, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received: 17 May 2016

Accepted after revision: 05 February 2016

Publication Date:
08 January 2018 (online)

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Summary

An 8.5-year-old, 98 kg female mountain sheep presented with bilateral exophthalmos with reduced retropulsion of the globes, impairing physiologic eyelid closure, sanguineous ocular discharge, as well as swelling of the eyelids and periocular skin. Bilateral vitreal hemorrhage hindering examination of the fundus was further noticed. Systemic signs included reduced general demeanour, presence of a firm mass in the left half of the mammary gland, multiple masses in the area of the vulva and a mass between the shoulder blades. Complete diagnostic work-up, i. e. complete blood count, blood chemistry and coagulation status, fine needle aspiration of periocular swellings and incisional biopsy of the vulvar masses revealed a diagnosis of malignant B-cell lymphoma. Due to the deterioration in general demeanour and rapid progression of exophthalmos, resulting in bilateral corneal ulceration, despite symptomatic medical treatment, the ewe was humanely euthanized. Gross necropsy and histopathology of select tissue samples confirmed the diagnosis of multicentric malignant B-cell lymphoma. To the authors’ knowledge, this is the first report of multicentric malignant B-cell lymphoma involving the ocular adnexa in sheep.

Zusammenfassung

Ein 8,5 Jahre altes, 98 kg schweres weibliches Bergschaf wurde mit bilateralem Exophthalmus mit erschwerter Retropulsion des Augapfels, unvollständigem physiologischem Lidschluss, sanguinösem Augenausfluss sowie einer Schwellung der Augenlider und der periokulären Haut vorgestellt. Ferner bestand eine bilaterale Glaskörperblutung, die eine Untersuchung des Fundus behinderte. Zeichen einer systemischen Erkrankung des Tieres umfassten ein reduziertes Allgemeinverhalten, die Präsenz einer festen Masse in der linken Hälfte der Mamma, multiple Massen im Bereich der Vulva und eine Masse zwischen den Schulterblättern. Eine umfassende diagnostische Aufarbeitung mittels Differenzialblutbild, blutchemischer Untersuchung, Blutgerinnungstest, Feinnadelaspirationsbiopsie der periokulären Schwellungen und inzisionaler Biopsie der Massen im Bereich der Vulva mit histo logischer Untersuchung ergaben die Diagnose eines malignen B-Zell-Lymphoms. Da sich das Allgemeinbefinden des Tieres rasch verschlechterte und durch zunehmenden Exophthalmus beidseits korneale Ulzera auftraten, wurde das Schaf euthanasiert. Die pathologische Untersuchung des Tierkörpers und die histopathologische Untersuchung ausgewählter Gewebeproben bestätigten die Diagnose eines multizentrischen malignen B-Zell-Lymphoms. Nach Wissen der Autoren ist dies der erste Bericht über ein multizentrisches malignes B-Zell-Lymphom mit Beteiligung der okulären Adnexe beim Schaf.

Keywords

Adnexa - eye - lymphoma - neoplasia - retrobulbar - sheep

Schlüsselwörter

Adnexe - Auge - Lymphom - Neoplasie - retrobulbär - Schaf
 

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