Expression of Concern

Concerns have been raised about the originality and possibly duplicity of figures used in articles published by Dr. Kenji Okajima's group in Thrombosis and Haemostasis. This concerns the following articles:

● Yuksel M, Okajima K, Uchiba M, Horiuchi S, Okabe H. Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes Thromb Haemost 2002; 88: 267–273.

● Harada N, Okajima K, Yuksel M, Isobe H. Contribution of capsaicin-sensitive sensory neurons to antithrombin-induced reduction of ischemia/reperfusion-induced liver injury in rats. Thromb Haemost 2005; 93: 48–56.

● Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Shimozawa N, Okabe H. Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo. Thromb Haemost 2005; 94: 136–145.

Although the authors have provided new figures, Thrombosis and Haemostasis has no means of establishing correctness of these figures and thus is publishing this Expression of Concern.