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Thromb Haemost 2010; 104(04): 681-692
DOI: 10.1160/TH10-03-0183
Review Article
Schattauer GmbH

The vessel wall: A forgotten player in post thrombotic syndrome

Scott DeRoo
1   Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
,
K. Barry Deatrick
1   Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
,
Peter K. Henke
1   Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
› Author Affiliations Financial support:This study was supported in part by NIH HL083918 and a Summer Student Biomedical Research fellowship.
Further Information

Publication History

Received: 20 March 2010

Accepted after major revision: 08 June 2010

Publication Date:
24 November 2017 (online)

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Summary

Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thrombotic inflammatory insult. Herein, we review what is currently known about this process with emphasis on the matrix, mediators, and vascular medial smooth muscle response after thrombotic injury. Translational therapies and potential future agents are reviewed.

Keywords

Cell-matrix interactions - deep-vein thrombosis - inflammation - matrix metalloproteinases
 

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