Thromb Haemost 2007; 97(03): 355-363
DOI: 10.1160/TH06-08-0470
Theme Issue Article
Schattauer GmbH

Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis

Erhard Hofer
1   Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna. Austria
,
Bernhard Schweighofer
1   Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna. Austria
› Author Affiliations
Further Information

Publication History

Received 29 August 2006

Accepted after resubmission 22 February 2006

Publication Date:
28 November 2017 (online)

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Summary

New vessel formation during development and in the adult is triggered by concerted signals of largely endothelial-specific receptors for ligands of the VEGF, angiopoietin and ephrin families. The signals and genes induced by these receptors operate in the context of additional signals transduced by non-endothelial specific growth factor receptors, inflammatory cytokine receptors as well as adhesion molecules. We summarize here available data on characteristic signaling of the VEGF receptor-2 and the current state of knowledge regarding the additional different receptor tyrosine kinases of the VEGF, Tie and Ephrin receptor families. Furthermore, the potential cross-talk with signals induced by other growth factors and inflammatory cytokines as well as the modulation by VE-cadherin is discussed.