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Thromb Haemost 2004; 92(06): 1175-1181
DOI: 10.1160/TH04-02-0127
Theme Issue Article
Schattauer GmbH

Aspirin and coronary artery disease

Andrew O. Maree
1   Department of Clinical Pharmacology, The Royal College of Surgeons in Ireland, Dublin, Ireland
,
Desmond J. Fitzgerald
2   Conway Institute, University College Dublin, Ireland
› Author AffiliationsFinancial support: The authors’ work is supported by grants from the Irish Heart Foundation and Higher Education Authority in Ireland.
Further Information

Publication History

Received 25 February 2004

Accepted after revision 14 June 2004

Publication Date:
02 December 2017 (online)

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Summary

Coronary atherosclerosis (CAD), a chronic inflammatory disorder, arises when genetic susceptibility, intercurrent conditions such as diabetes and hypertension and environmental factors interact. Although CAD can remain stable for many years, thrombus formation at sites of plaque rupture may lead to unstable angina (UA) or myocardial infarction (MI). Already recognised as the central component of coronary thrombosis, platelets, through their interaction with monocytes and endothelial cells, may also be involved at the earliest stages of atheromatous plaque evolution. Aspirin, the prototype antiplatelet agent, covalently and irreversibly inhibits cyclooxygenase (COX) and thus inhibits platelet thromboxane (TX) A2 biosynthesis. Anti-oxidant properties and the ability to modulate transcription of immunologically important genes have also been attributed to aspirin. Non-selective COX inhibition, however, predisposes to bleeding, predominantly secondary to dosedependent gastro-intestinal toxicity. The emerging concept of “aspirin resistance” coincides with the development of alternative antiplatelet therapy and point-of-care platelet function assays. Though variable aspirin pharmacokinetics may explain many cases, heritable factors, inducible platelet COX expression and isoprostane formation may also contribute. In future, risk factor screening and point-of-care platelet function assay may identify vulnerable patients who would benefit from additional or alternate antiplatelet therapy.

Keywords

Atherosclerosis - coronary thrombosis - antiplatelet - aspirin resistance - heritable
 

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