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Thromb Haemost 2004; 91(06): 1152-1157
DOI: 10.1160/TH03-10-0660
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Erythrocyte sodium/lithium countertransport is associated with thrombotic and fibrinolytic factors in 58-year-old men

Hans Herlitz
1   Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden
,
Lena Bokemark
2   Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
,
Björn Fagerberg
2   Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
› Author Affiliations
Further Information

Publication History

Received 29 October 2003

Accepted after resubmission 01 March 2003

Publication Date:
02 December 2017 (online)

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Summary

The metabolic syndrome, in which insulin resistance is the core feature, is associated both with dysregulation of thrombosis/ fibrinolysis and erythrocyte sodium/lithium countertransport (SLC).To investigate this further we designed a cross-sectional study to examine whether factors involved in coagulationand fibrinolysis systems were associated with SLC independently of insulin resistance in 93 58-year-old men. SLC was in univariate analysis positively correlated with PAI-1 activity (r = 0.35, p <0.01), tPA antigen (r = 0.38, p <0.01), von Willebrand factor (r = 0.25, p <0.05), protein S (r = 0.26, p <0.05), and C (r = 0.30, p <0.01), and negatively associated with tPA activity(r = −0.28, p <0.01). Since these correlations could be influenced by the components of the metabolic syndrome itself, a separate analysis with adjustment for glucose infusion rate (GIR), plasma insulin, body fat, sagittal diameter of the abdomen (SD) and log serum triglyceride concentration (TG) was conducted. Then SLC was associated with tPA antigen independent of GIR, plasma insulin, body fat, SD and TG. SLC was also associated with protein C independent of GIR, insulin, body fat and SD but not TG. In conclusion, we found a relationship between SLC and the fibrinolytic system that was not related to the metabolic syndrome.

Keywords

Sodium/lithium countertransport - fibrinolysis - coagulation - metabolic syndrome - renin-angiotensin system
 

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