Indoline Synthesis via a C-H Insertion-Carbopalladation-Cyclization
Sequence

C. E. Houlden; C. D. Bailey; J. G. Ford; M. R. Gagné; G. C. Lloyd-Jones; K. I. Booker-Milburn

doi:10.1055/s-2008-1078233

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2008(10): 1088-1088
DOI: 10.1055/s-2008-1078233

Metal-Mediated Synthesis

Indoline Synthesis via a C-H Insertion-Carbopalladation-Cyclization Sequence

Contributor(s): Paul Knochel, Tobias Thaler
C. E. Houlden, C. D. Bailey, J. G. Ford, M. R. Gagné, G. C. Lloyd-Jones*, K. I. Booker-Milburn*
University of Bristol and AstraZeneca PR&D, Macclesfield, UK; University of North Carolina at Chapel Hill, USA

Further Information

Publication History

Publication Date:
22 September 2008 (online)

Permissions and Reprints

Significance

A novel one-pot access to functionalized indolines via a Pd(II)-catalyzed C-H activation-carbopalladation-cyclization sequence has been disclosed. The presence of a palladium tosylate species was observed to be crucial for the reaction.