Catalytic Hydrochlorination of Unactivated Olefins

B. Gaspar; E. M. Carreira

doi:10.1055/s-2008-1078232

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Synfacts 2008(10): 1095-1095
DOI: 10.1055/s-2008-1078232

Metal-Mediated Synthesis

Catalytic Hydrochlorination of Unactivated Olefins

Contributor(s): Paul Knochel, Tobias Thaler
B. Gaspar, E. M. Carreira*
ETH Hönggerberg, Zürich, Switzerland

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Publication History

Publication Date:
22 September 2008 (online)

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Significance

An expedient method for the hydrochlorination of unactivated olefins has been developed. In this reaction, cheap and readily available tosyl chloride acts as chlorine source and is transferred to the respective terminal olefin via cobalt catalysis. In all reactions the Markovnikov products were obtained regiospecifically.