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Synfacts 2008(10): 1097-1097
DOI: 10.1055/s-2008-1078221
DOI: 10.1055/s-2008-1078221
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
In-Mediated Synthesis of Allenic Esters and their Cyclization to 2-Naphthoates
C. Park, P. H. Lee*
Kangwon National University, Chunchon, Korea
Further Information
Publication History
Publication Date:
22 September 2008 (online)
Significance
Functionalized α-hydroxyallenic esters combine two useful functions: an allenic alcohol and an allenic ester, and therefore are useful intermediates in synthetic chemistry, as well as structural units of many natural compounds. Herein, a simple and general method for their synthesis, based on the formation of organoindium intermediates, is described. These compounds were shown to undergo an interesting Au+-catalyzed cyclization to 2-naphthoate derivatives.