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Synfacts 2008(10): 1112-1112  
DOI: 10.1055/s-2008-1078201
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Selective Debenzylation of Aryl Benzyl Ethers

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
L. Zhou, W. Wang, L. Zuo*, S. Yao, W. Wang*, W. Duan*
Shanghai Institutes of Biological Sciences, East China University of Science and Technology, Shanghai, P. R. of China and University of New Mexico, Albuquerque, USA
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Debenzylation of aryl benzyl ethers by a heterogeneous silica gel supported sodium hydrogen sulfate (NaHSO4˙SiO2) is described. Thus, various aryl benzyl ethers 1 (1 mmol) were treated with NaHSO4˙SiO2 (500 mg) in thiophene or anisole to give the corresponding debenzylated phenols 2 in 52-96% yields (12 examples).