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Synfacts 2008(10): 1022-1022  
DOI: 10.1055/s-2008-1078187
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Palmerolide A

Contributor(s): Philip Kocienski, Indu Dager
K. C. Nicolaou*, Y. P. Sun, R. Guduru, B. Banerji, D. Y.-K. Chen*
Institute of Chemical and Engineering Sciences, Singapore
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Palmerolide A was isolated from Synoicum adareanum and exhibits potent and selective activity against the melanoma cancer cell line UACC-62. This highly convergent synthesis is based upon four key reactions including an olefin ring-closing metathesis of a substrate B containing eight double bonds and the enamide side chain in place to construct the macrocycle.