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Synfacts 2008(10): 1066-1066  
DOI: 10.1055/s-2008-1078140
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Diastereoselective Pd-Catalyzed Oxidative Cyclization of Enynes

Contributor(s): Hisashi Yamamoto, Marina Naodovic
G. Yin, G. Liu*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

The novelty of the oxidative cyclization methodology described in this report is the utility of hydrogen peroxide as a stoichiometric oxidizing agent. The protocol provides structurally complex cycloadducts with high level of diaste­reoselectivity and good yields.