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Synfacts 2008(10): 1048-1048  
DOI: 10.1055/s-2008-1078036
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Organomercury-Induced Fluorogenic Unmasking for Biological Sensing

Contributor(s): Timothy M. Swager, Rebecca R. Parkhurst
R. M. Franzini, E. T. Kool*
Stanford University, USA
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

The authors report the design and synthesis of a probe for point mutation detection with single nucleotide specificity. Two DNA oligonucleotides were functionalized such that when brought together by binding to a complementary DNA strand they react to unmask a fluorophore.