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Synfacts 2008(9): 0967-0967  
DOI: 10.1055/s-2008-1077999
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Arylzinc Addition to Aldehydes

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
A. M. DeBerardinis, M. Turlington, L. Pu*
University of Virginia, Charlottesville, USA
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

In the present work, the authors utilize Knochel’s method for diarylzinc preparation (Angew. Chem. Int. Ed. 2004, 43, 1017) and (S)-H8BINOL-derived L1 to generate a highly reactive and enantioselective catalytic system for the addition of various functionalized arylzincs to aldehydes. Interestingly, when L1 was not added the reaction rate was significantly decreased.