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Synfacts 2008(7): 0678-0678  
DOI: 10.1055/s-2008-1077859
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Phakellin

Contributor(s): Philip Kocienski, Zofia Komsta
S. Wang, D. Romo*
Texas A&M University, USA
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

Phakellines are a family of sponge alkaloids containing the pyrrole-imidazole moiety. (+)-Phakellin can be obtained by hydrogenolysis of (+)-dibromophakellin, a product isolated from Pseudoaxinyssa cantharella. The first enantioselective synthesis of (+)-phakellin is presented. The other member of the family, (+)-monobromo­phakellin, can be synthesised from H in two steps.