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Synfacts 2008(7): 0748-0748
DOI: 10.1055/s-2008-1077827
DOI: 10.1055/s-2008-1077827
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Palladium-Catalyzed Cleavage of C-C Triple Bonds with Molecular Oxygen
A. Wang, H. Jiang*
South China University of Technology, Guangzhou, P. R. of China
Further Information
Publication History
Publication Date:
20 June 2008 (online)
Significance
A Pd-catalyzed cleavage of alkynes with molecular oxygen in various alcohols leading to the corresponding carboxylic esters has been realized. ZnCl2 ·2H2O was hereby found to be the most suitable Lewis acid for promoting the cleavage. The reaction was successfully applied to both symmetrically and unsymmetrically substituted alkynes.