Synthesis of Palmitoyl Caprazol

S. Hirano; S. Ichikawa; A. Matsuda

doi:10.1055/s-2008-1072704

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2008(5): 0455-0455
DOI: 10.1055/s-2008-1072704

Synthesis of Natural Products and Potential Drugs

Synthesis of Palmitoyl Caprazol

Contributor(s): Philip Kocienski
S. Hirano, S. Ichikawa*, A. Matsuda*
Hokkaido University, Sapporo, Japan

Further Information

Publication History

Publication Date:
23 April 2008 (online)

Permissions and Reprints

Significance

Palmitoyl caprazol inhibits Mra Y translocase, a key enzyme in bacterial peptidoglycan synthesis. Its antibacterial activity towards Mycobacterium smegmatis, MRSA- and vancomycin-resistant enterococci is comparable to caprazamycin.