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Synfacts 2008(5): 0496-0496  
DOI: 10.1055/s-2008-1072642
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Chiral Glutamic Acid By Conjugate Addition

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
S. Kobayashi*, T. Tsubogo, S. Saito, Y. Yamashita
The University of Tokyo, Japan
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

One of the most efficient preparation methods of glutamic acid derivatives is 1,4-addition of glycine derivatives to α,β-unsaturated esters or amides. The authors report the first dia­stereo- and enantioselective synthesis of 3-substituted glutamic acid derivatives using chiral calcium catalysts. The product could be converted into the free glutamic acid derivatives in good yields.