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Synfacts 2008(5): 0514-0514  
DOI: 10.1055/s-2008-1072518
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Arylation of (Het)arenes with Arylboronic Acids

Contributor(s): Paul Knochel, Andrei Gavryushin
S.-D. Yang, C.-L. Sun, Z. Fang, B.-J. Li, Y.-Z. Li, Z.-J. Shi*
Peking Universtiy and State Key Laboratory of Organometallic Chemistry, Shanghai, P. R. of China
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

Direct coupling of C-H bonds has recently attracted a lot of attention, as in many cases it is more useful to synthetic chemistry than traditional coupling of halides. Herein, an elegant Pd-catalyzed arylation of arenes and heteroarenes via C-H activation is described. This method allows a simple direct and regioselective introduction of an arene into activated positions of electron-rich aromatic rings. Cheap and environmentally benign oxygen is used as the reoxidant for Pd.