Tetra- and Monoorganotin Reagents in Palladium-Mediated Cross-Coupling Reactions for the Labeling with Carbon-11 of PET Tracers

Thomas Bourdier; Michael Huiban; Aline Huet; Franck Sobrio; Eric Fouquet; Cécile Perrio; Louisa Barré

doi:10.1055/s-2008-1032206

PAPER

Tetra- and Monoorganotin Reagents in Palladium-Mediated Cross-Coupling Reactions for the Labeling with Carbon-11 of PET Tracers

Thomas Bourdier^a, Michael Huiban^a, Aline Huet^b, Franck Sobrio^a, Eric Fouquet^b, Cécile Perrio*^a, Louisa Barré*^a
^a Groupe de Développements Méthodologiques en Tomographie par Emission de Positons, UMR CEA 2E, Université de Caen-Basse Normandie, Centre Cyceron, 15 Boulevard Henri Becquerel, 14070 Caen Cedex, France
^b Laboratoire de Chimie Organique et Organométallique, UMR CNRS 3802, Université Bordeaux I, 351 Cours de la Libération, 33405 Talence Cedex, France
Fax: +33(2)31470275; e-Mail: perrio@cyceron.fr; e-Mail: barre@cyceron.fr;

Abstract

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Abstract

The palladium-catalyzed cross-coupling reactions between a (trimethylstannyl)arene and [¹¹C]methyl iodide (Stille reaction) or between an aryl halide and a [¹¹C]monomethyltin reagent issued from Lappert’s stannylene, were developed for the synthesis of polyfunctional [¹¹C]methyl quinolines and quinolinimides as potential tracers for positron emission tomography (PET).

Key words

positron emission tomography - carbon-11 - Stille - monoorganotin - [¹¹C]methyl iodide

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