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Am J Perinatol 1993; 10(5): 401-403
DOI: 10.1055/s-2007-994772
ORIGINAL ARTICLE

© 1993 by Thieme Medical Publishers, Inc.

Pregnancy-Induced Hypertension and Early Neonatal Death: A Case-Control Study

Jun Zhang1 , Wen-wei Cai2 , David J. Lee3
  • 1Carolina Population Center and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;
  • 2Department of Maternal and Child Health, Shanghai Medical University, Shanghai, China;
  • 3Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, Florida
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Literature on the association between pregnancy-induced hypertension and early neonatal death is limited. The present case-control study consisted of 342 early neonatal deaths and 523 frequency-matched controls. After controlling for other factors such as infant sex, gravidity, maternal age, threatened abortion, and maternal anemia, moderate to severe pregnancy-induced hypertension was associated with an increased risk of early neonatal death with apparent dose-effect gradients (odds ratio = 1.8 for moderate and 2.2 for severe). The biologic plausibility of pregnancy-induced hypertension as a cause of neonatal mortality is discussed.