Download PDF
Am J Perinatol 1996; 13(1): 11-13
DOI: 10.1055/s-2007-994194
ORIGINAL ARTICLE

© 1996 by Thieme Medical Publishers, Inc.

Effect of Dehydroepiandrosterone Sulfate on Maternal Cardiac Function in Term Pregnancy

Toshiyuki Hata, Kanji Ryukoh, Ritsuto Fujiwaki, Kohkichi Hata, Manabu Kitao, Sumio Masumura
  • Departments of Obstetrics and Gynecology, and Physiology, Shimane Medical University, Izumo, Japan
Further Information

Publication History

Publication Date:
04 March 2008 (online)

Also available at
    Permissions and Reprints

ABSTRACT

To search for possible effect of dehydroepiandrosterone sulfate (DHAS) on maternal cardiac function in term pregnancy, impedance cardiographic assessments were made on 15 normal full-term pregnant women before and 5, 10, 15, 20, 25, and 301 minutes after the administration of a 200 mg intravenous dose of DHAS in 20 mL of 5% dextrose. The cardiac output, stroke volume, heart rate, and mean arterial pressure were recorded. Maternal cardiac output increased from baseline by 20% (p < 0.05) after 15 minutes and the mean increase in stroke volume was 25% (p < 0.05) after 15 minutes. No change was found in heart rate or mean arterial blood pressure. DHAS induces a significant increase in both maternal stroke volume and cardiac output without change in heart rate or mean arterial pressure, which suggests a possible increase in cardiac contractility in term pregnancy.

Keywords

Dehydroepiandrosterone sulfate - term pregnancy - impedance cardiography - cardiac output