Synlett 2007(20): 3160-3164  
DOI: 10.1055/s-2007-992377
LETTER
© Georg Thieme Verlag Stuttgart · New York

Hydrogen-Bond-Promoted C-C Bond-Forming Reaction: Catalyst-Free Michael Addition Reactions in Ethanol

Seiji Shirakawa*, Shoichi Shimizu
Department of Applied Molecular Chemistry and High Technology Research Center, College of Industrial Technology, Nihon University, Narashino, Chiba, 275-8575, Japan
Fax: +81(47)4742579; e-Mail: s5siraka@cit.nihon-u.ac.jp;
Further Information

Publication History

Received 20 September 2007
Publication Date:
21 November 2007 (online)

Abstract

A practical protocol for catalyst-free Michael addition reactions in ethanol was developed. The reaction was promoted efficiently in alcohol without any additives, and the importance of hydrogen-bonding activation was suggested.

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Amount of EtOH could be reduced to 0.10 mL without loss of reactivity.