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Synlett 2007(20): 3160-3164
DOI: 10.1055/s-2007-992377
DOI: 10.1055/s-2007-992377
LETTER
© Georg Thieme Verlag Stuttgart · New York
Hydrogen-Bond-Promoted C-C Bond-Forming Reaction: Catalyst-Free Michael Addition Reactions in Ethanol
Further Information
Received
20 September 2007
Publication Date:
21 November 2007 (online)
Publication History
Publication Date:
21 November 2007 (online)
Abstract
A practical protocol for catalyst-free Michael addition reactions in ethanol was developed. The reaction was promoted efficiently in alcohol without any additives, and the importance of hydrogen-bonding activation was suggested.
Key words
alcohols - green chemistry - Michael additions - solvent effects - enols
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References and Notes
Amount of EtOH could be reduced to 0.10 mL without loss of reactivity.