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Synfacts 2007(12): 1327-1327  
DOI: 10.1055/s-2007-991390
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

PS-NHC-Palladium Catalyst for Sonogashira Coupling

Contributor(s): Yasuhiro Uozumi, Hiroe Takenaka
J.-H. Kim, D.-H. Lee, B.-H. Jun, Y.-S. Lee*
Seoul National University, Korea
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

Green switching of the Sonogashira coupling reaction was achieved with a polymeric heterogeneous palladium catalyst under aqueous and copper-free conditions. Polystyrene-supported bis(N-heterocyclic carbene)-palladium complex 1 was prepared from the polymeric NHC ligand precursor. The polymeric NHC-Pd complex catalyzed the coupling of aryl halides (I or Br) with terminal alkynes in DMF-H2O in the absence of copper salts. Good substrate tolerance was exhibited (15 entries).