Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(12): 1226-1226
DOI: 10.1055/s-2007-991307
DOI: 10.1055/s-2007-991307
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Pinnaic Acid
S. Xu, H. Arimoto*, D. Uemura
Tohoku University, Sendai and Nagoya University, Japan
Further Information
Publication History
Publication Date:
22 November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200712/lookinside/thumbnails/10.1055-s-2007-991307-1.jpg)
Significance
Pinnaic acid, isolated from the Okinawan bivalve Pinna muricata, inhibits activity of cytosolic 85 kDa phospholipase (cPLA2) and therefore has anti-inflammatory potential. Markworthy steps of the synthesis are: (1) a Pd-catalyzed trimethylenemethane [3+2] cyclization (B→D) and (2) a tandem hydrogenation-cyclization (I→J).