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Synfacts 2007(11): 1197-1197  
DOI: 10.1055/s-2007-991226
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Iron-Catalyzed Cross-Coupling Reaction Between Alkenyl Grignard Reagents and Alkyl Halides

Contributor(s): Paul Knochel, Tobias Thaler
G. Cahiez*, C. Duplais, A. Moyeux
Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique Cergy-Pontoise, France
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

This publication reports the first iron-catalyzed cross-coupling reactions between secondary alkyl halides and alkenyl Grignard reagents. The reaction proceeds stereoselectively retaining the configuration of the double bond. Sensitive functional groups such as ester and nitrile groups are tolerated.