Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000054.xml
Pharmacopsychiatry 2007; 40(5): 201-202
DOI: 10.1055/s-2007-985884
DOI: 10.1055/s-2007-985884
Letter
© Georg Thieme Verlag KG Stuttgart · New York
Reversible Paroxetine-Induced Symptomatic Hypothyroidism
Further Information
Publication History
received 02.01.2007
revised 12.06.2007
accepted 03.07.2007
Publication Date:
17 September 2007 (online)
Paroxetine is a selective serotonin reuptake inhibitor (SSRI). SSRIs are widely used as antidepressants and have rare but severe adverse effects [1], particularly on thyroid hormone [2]. We present the first case, to the best of our knowledge, of reversible paroxetine-induced symptomatic hypothyroidism.
References
- 1 Denger D, Grohmann R, Kropp S, Ruther E, Bender S, Engel RR, Schmidt LG. Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP. Pharmacopsychiatry. 2004; 37 ((Suppl 1)) S39-S45
- 2 GlaxoSmithKline USA . Prescribing information. http://us.gsk.com/products/assets/us_paxil.pdf
- 3 Konig F, Hauger B, Hippel C von, Wolfersdorf M, Kaschka WP. Effect of paroxetine on thyroid hormone levels in severe depressed patients. Neuropsychobiology. 2000; 42 135-138
- 4 Sagud M, Pivac N, Muck-Seler D, Jakovljevic M, Mihaljevic-Peles A, Korsic M. Effect of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients. Neuropsychobiology. 2002; 45 139-143
Correspondence
M. Takahashi
Department of Psychiatry
Kitasato University School of Medicine
2-1-1 Asamizodai
228-8520
Sagamihara
Japan
Phone: +81/42/748 91 11
Fax: +8142765 35 70
Email: megumita@kitasato-u.ac.jp