Pharmacopsychiatry 2007; 40(5): 201-202
DOI: 10.1055/s-2007-985884
Letter

© Georg Thieme Verlag KG Stuttgart · New York

Reversible Paroxetine-Induced Symptomatic Hypothyroidism

M. Takahashi 1 , E. Sawayama 1 , T. Sawayama 1 , H. Miyaoka 1
  • 1Department of Psychiatry, Kitasato University School of Medicine, Sagamihara, Japan
Further Information

Publication History

received 02.01.2007 revised 12.06.2007

accepted 03.07.2007

Publication Date:
17 September 2007 (online)

Paroxetine is a selective serotonin reuptake inhibitor (SSRI). SSRIs are widely used as antidepressants and have rare but severe adverse effects [1], particularly on thyroid hormone [2]. We present the first case, to the best of our knowledge, of reversible paroxetine-induced symptomatic hypothyroidism.

References

  • 1 Denger D, Grohmann R, Kropp S, Ruther E, Bender S, Engel RR, Schmidt LG. Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP.  Pharmacopsychiatry. 2004;  37 ((Suppl 1)) S39-S45
  • 2 GlaxoSmithKline USA . Prescribing information.  http://us.gsk.com/products/assets/us_paxil.pdf
  • 3 Konig F, Hauger B, Hippel C von, Wolfersdorf M, Kaschka WP. Effect of paroxetine on thyroid hormone levels in severe depressed patients.  Neuropsychobiology. 2000;  42 135-138
  • 4 Sagud M, Pivac N, Muck-Seler D, Jakovljevic M, Mihaljevic-Peles A, Korsic M. Effect of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients.  Neuropsychobiology. 2002;  45 139-143

Correspondence

M. Takahashi

Department of Psychiatry

Kitasato University School of Medicine

2-1-1 Asamizodai

228-8520

Sagamihara

Japan

Phone: +81/42/748 91 11

Fax: +8142765 35 70

Email: megumita@kitasato-u.ac.jp