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DOI: 10.1055/s-2007-985148
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus
Publication History
received 02.06.2007
first decision 12.06.2007
accepted 04.07.2007
Publication Date:
09 October 2007 (online)
![](https://www.thieme-connect.de/media/eced/200801/lookinside/thumbnails/10.1055-s-2007-985148-1.jpg)
Abstract
Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82±0.65 vs. 1.53±0.60 μg/L, P<0.05). In T2DM patients, fasting plasma FGF-21 correlate negatively with fasting blood glucose (r=-0.31, P<0.05). Multiple regression analysis showed that FBG, plasma insulin and HOMAIS were independent influencing plasma FGF-21 levels. The present work suggests a potential role for FGF-21 in the pathogenesis of insulin resistance and T2DM.
Key words
FGF-21 - insulin resistance - T2DM
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Correspondence
Dr. G.-Y. YangPhD
Department of Endocrinology
The Second Affiliated Hospital
Chongqing Medical University
400010 Chongqing
China
Phone: +86/23/68 48 61 15
Fax: +86/23/68 48 61 15
Email: gangyiyang@yahoo.com.cn