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DOI: 10.1055/s-2007-981256
© Georg Thieme Verlag Stuttgart · New York
Evidenzbasierte Schwangerenvorsorge im Normalkollektiv
Publication History
Publication Date:
30 August 2007 (online)
Kernaussagen
Vorsorgeuntersuchungen stellen einen unverzichtbaren Bestandteil jeder Schwangerenbetreuung dar. Nicht alle routinemäßig angebotenen und durchgeführten Untersuchungen basieren jedoch auf harter Evidenz.
Vor diesem Hintergrund scheint eine Diskussion über Sinn und Nutzen gewisser routinemäßig durchgeführten Maßnahmen der Schwangerenvorsorge geboten. Anhand zahlreicher Cochrane-Metaanalysen über die Ergebnisse relevanter Studien wird die aktuelle Datenlage dargestellt:
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Es gibt keine durch Studien abgesicherten Gründe, bei unauffälligem Schwangerschaftsverlauf das Gewicht regelmäßig zu kontrollieren.
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Eine verringerte Anzahl an Vorsorgeuntersuchungen hat im Niedrigrisiko-Kollektiv keine Auswirkung auf verschiedene Parameter des Schwangerschaftsverlaufs. Empfehlenswert sind jedoch mindestens 4 Untersuchungen.
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Aufgrund der fehlenden Evidenz scheint die routinemäßige vaginale Untersuchung von Schwangeren ohne Spätabort oder frühe Frühgeburt in der Anamnese nicht empfehlenswert.
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Der Oxytocin-Belastungstest weist keinen gesicherten klinischen Nutzen auf, auch nicht bei Terminüberschreitung.
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Eine mütterliche Hypotonie gefährdet nicht die uteroplazentare Versorgung des Feten.
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Beschränkt man das Diabetes-Screening nur auf Risikopatientinnen, wird höchstens die Hälfte aller Fälle mit Gestationsdiabetes erkannt. Ein Screeningprogramm in Form eines oralen Glukose-Toleranztests für alle schwangeren Frauen scheint daher dringend geboten.
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Die intrapartale Gabe von Antibiotika kann die Rate an neonatalen Infektionen mit Streptokokken der Gruppe B signifikant senken.
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Das HIV-Screening sollte fester Bestandteil jeder Schwangerenvorsorge sein.
Literatur
- 1 Vetter K. Kontroversen in der Schwangerenbetreuung und Geburtshilfe. In Beweisnot?. gynäkologie + geburtshilfe. 2004; 2 1-3
- 2 Carr D B, Epplein M, Johnson C O. et al . A sister's risk: family history as a predictor of preeclampsia. Am J Obstet Gynecol. 2005; 193 965-972
- 3 Hjartardottir S, Leifsson B G, Geirsson R T, Steinthorsdottir V. Recurrence of hypertensive disorder in second pregnancy. Am J Obstet Gynecol. 2006; 194 916-920
- 4 Kim C, Berger D K, Chamany S. Recurrence of gestational diabetes: a systematic review. Diabetes Care. 2007; 30 1314-1319
- 5 Dawes M G, Grudzinskas J G. Repeated measurement of maternal weight during pregnancy. Is this a useful practice?. Br J Obstet Gynaecol. 1991; 98 189-194
- 6 Buekens P, Alexander S, Boutsen M. et al . Randomised controlled trial of routine cervical examinations in pregnancy. European Community Collaborative Study Group on Prenatal Screening. Lancet. 1994; 344 841-844
- 7 Carroli G, Villar J, Piaggio G. et al . WHO systematic review of randomised controlled trials of routine antenatal care. Lancet. 2001; 357 1565-1570
-
8 Villar J, Carroli G, Khan-Neelofur D. et al .Patterns of routine antenatal care for low-risk pregnancy. Cochrane Database Syst Rev 2001: CD 000934
- 9 Crowther C A, Kornman L, O'Callaghan S. et al . Is an ultrasound assessment of gestational age at the first antenatal visit of value? A randomised clinical trial. Br J Obstet Gynaecol. 1999; 106 1273-1279
-
10 Neilson J P. Ultrasound for fetal assessment in early pregnancy. Cochrane Database Syst Rev 2000: CD 000182
-
11 National, Health CCfWsaCs .Antenatal care: routine care for the healthy pregnant woman. Accessed online January 04, 2006, at: www.rcog.org.uk
: > Guidelines > National Evidence-Based Clinical Guidelines > Antenatal Care Routine for the Healthy Pregnant Woman.pdf. 2003
- 12 Langer B, Caneva M P, Schlaeder G. Routine prenatal care in Europe: the comparative experience of nine departments of gynaecology and obstetrics in eight different countries. Eur J Obstet Gynecol Reprod Biol. 1999; 85 191-198
-
13 Bricker L, Neilson J P. Routine ultrasound in late pregnancy (after 24 weeks gestation). Cochrane Database Syst Rev 2000: CD 001451
- 14 Heath V C, Daskalakis G, Zagaliki A. et al . Cervicovaginal fibronectin and cervical length at 23 weeks of gestation: relative risk of early preterm delivery. Br J Obstet Gynaecol. 2000; 107 1276-1281
- 15 Iams J D, Goldenberg R L, Meis P J. et al . The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N Engl J Med. 1996; 334 567-572
- 16 de Carvalho M H, Bittar R E, Brizot Mde L. et al . Prediction of preterm delivery in the second trimester. Obstet Gynecol. 2005; 105 532-536
-
17 Darcy M A, Watson L F, Rayner J, Rowlands S. Risk scoring systems for predicting preterm birth with the aim of reducing associated adverse outcomes. Cochrane Database Syst Rev 2004: CD 004902
- 18 Malone F D, Canick J A, Ball R H. et al . First-trimester or second-trimester screening, or both, for Down's syndrome. N Engl J Med. 2005; 353 2001-2011
-
19 Pattison N, McCowan L. Cardiotocography for antepartum fetal assessment. Cochrane Database Syst Rev 2000: CD 001068
-
20 Schneider K TM, Butterwegge M, Daumer M. et al .Anwendung des CTG während Schwangerschaft und Geburt. AWMF 2004; 015 / 036
- 21 Figueras F, Martinez J M, Puerto B. et al . Contraction stress test versus ductus venosus Doppler evaluation for the prediction of adverse perinatal outcome in growth-restricted fetuses with non-reassuring non-stress test. Ultrasound Obstet Gynecol. 2003; 21 250-255
- 22 Lagrew Jr D C. The contraction stress test. Clin Obstet Gynecol. 1995; 38 11-25
- 23 Staisch K J, Westlake J R, Bashore R A. Blind oxytocin challenge test and perinatal outcome. Am J Obstet Gynecol. 1980; 138 399-403
-
24 Crowley P. Interventions for preventing or improving the outcome of delivery at or beyond term. Cochrane Database Syst Rev 2000: CD 000170
- 25 Levran D, Shoham Z, Geranek M. et al . The value of amnioscopy in surveillance of postdate pregnancy. Aust N Z J Obstet Gynaecol. 1988; 28 271-274
- 26 Weber S, Schneider K T, Bung P. et al . Effects of compression stockings on blood circulation in late pregnancy. Geburtshilfe Frauenheilkd. 1987; 47 395-400
- 27 Crowther C A, Hiller J E, Moss J R. et al . Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005; 352 2477-2486
- 28 Langer O, Yogev Y, Most O, Xenakis E M. Gestational diabetes: the consequences of not treating. Am J Obstet Gynecol. 2005; 192 989-997
- 29 Whalley P. Bacteriuria of pregnancy. Am J Obstet Gynecol. 1967; 97 723-738
- 30 Millar L K, Cox S M. Urinary tract infections complicating pregnancy. Infect Dis Clin North Am. 1997; 11 13-26
-
31 Smaill F. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev 2001: CD 000490
-
32 McDonald H, Brocklehurst P, Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2007: CD 000262
- 33 Kiss H, Petricevic L, Husslein P. Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery. Brit Med J. 2004; 329 371
-
34 Brocklehurst P, Rooney G. Interventions for treating genital Chlamydia trachomatis infection in pregnancy. Cochrane Database Syst Rev 2000: CD 000054
- 35 Postma M J, Bakker A, Welte R. et al . Screening for asymptomatic Chlamydia trachomatis infection in pregnancy; cost-effectiveness favorable at a minimum prevalence rate of 3 % or more. Ned Tijdschr Geneeskd. 2000; 144 2350-2354
- 36 Mardh P A. Influence of infection with Chlamydia trachomatis on pregnancy outcome, infant health and life-long sequelae in infected offspring. Best Pract Res Clin Obstet Gynaecol. 2002; 16 847-864
- 37 Nigro G, Anceschi M M, Cosmi E V. Clinical manifestations and abnormal laboratory findings in pregnant women with primary cytomegalovirus infection. Br J Obstet Gynaecol. 2003; 110 572-577
- 38 Ville Y. The megalovirus. Ultrasound Obstet Gynecol. 1998; 12 151-153
- 39 Yow M D, Demmler G J. Congenital cytomegalovirus disease – 20 years is long enough. N Engl J Med. 1992; 326 702-703
- 40 Enders G, Bader U, Lindemann L. et al . Prenatal diagnosis of congenital cytomegalovirus infection in 189 pregnancies with known outcome. Prenat Diagn. 2001; 21 362-377
- 41 Adler S P, Finney J W, Manganello A M, Best A M. Prevention of child-to-mother transmission of cytomegalovirus by changing behaviors: a randomized controlled trial. Pediatr Infect Dis J. 1996; 15 240-246
- 42 Wong V C, Ip H M, Reesink H W. et al . Prevention of the HBsAG carrier state in newborn infants of mothers who are chronic carriers of HBsAG and HBeAG by administration of hepatitis-B vaccine and hepatitis-B immunoglobulin. Double-blind randomised placebo-controlled study. Lancet. 1984; 1 921-926
-
43 ACOG .Viral hepatitis in pregnancy. ACOG Education Bulletin 1992; 248
- 44 Connor E M, Sperling R S, Gelber R. et al . Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994; 331 1173-1180
- 45 Mandelbrot L, Le Chenadec J, Berrebi A. et al . Perinatal HIV-1 transmission: interaction between zidovudine prophylaxis and mode of delivery in the French Perinatal Cohort. Jama. 1998; 280 55-60
-
46 Smaill F. Intrapartum antibiotics for group B streptococcal colonisation. Cochrane Database Syst Rev 2000: CD 000115
- 47 CDC . Prevention of Group B streptococcal disease: a public health perspective. Morbidity Mortality Weekly Report. 1996; 45 1-24
- 48 Benitz W E, Gould J B, Druzin M L. Preventing early-onset group B streptococcal sepsis: strategy development using decision analysis. Pediatrics. 1999; 103 e76
- 49 Ingraham N RJr. The value of penicillin alone in the prevention and treatment of congenital syphilis. Acta Derm Venereol Suppl (Stockh). 1950; 31 60-87
- 50 Goh B T, van Voorst Vader P C. European guideline for the management of syphilis. Int J STD AIDS. 2001; 12 14-26
-
51 Walker G J. Antibiotics for syphilis diagnosed during pregnancy. Cochrane Database Syst Rev 2001: CD 001143
- 52 Martin D, Bertrand J, McKegney C. et al . Congenital syphilis surveillance and newborn evaluation in a low-incidence state. Arch Pediatr Adolesc Med. 2001; 155 140-144
- 53 van Voorst Vader P C. Syphilis management and treatment. Dermatol Clin. 1998; 16 699-711 , xi
- 54 Gross U. Prevalence and public-health-aspects of toxoplasmosis. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2004; 47 692-697
- 55 Hohlfeld P, Daffos F, Thulliez P. et al . Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J Pediatr. 1989; 115 765-769
-
56 Peyron F, Wallon M, Liou C, Garner P. Treatments for toxoplasmosis in pregnancy. Cochrane Database Syst Rev 2000: CD 001684
- 57 Lebech M, Andersen O, Christensen N C. et al . Feasibility of neonatal screening for toxoplasma infection in the absence of prenatal treatment. Danish Congenital Toxoplasmosis Study Group. Lancet. 1999; 353 1834-1837
- 58 Wallon M, Liou C, Garner P, Peyron F. Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy. Brit Med J. 1999; 318 1511-1514
- 59 Steer P, Alam M A, Wadsworth J, Welch A. Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. Brit Med J. 1995; 310 489-491
- 60 Mello G, Parretti E, Cioni R. et al . Individual longitudinal patterns in biochemical and hematological markers for the early prediction of pre-eclampsia. J Matern Fetal Neonatal Med. 2002; 11 93-99
-
61 Pfleiderer A, Breckwoldt M, Martius (Hrsg) G. Gynäkologie und Geburtshilfe. 4. Aufl. Thieme, Stuttgart 2001
-
62 Petersen E. Infektionen in Gynäkologie und Geburtshilfe. Thieme, Stuttgart 2003
Prof. Dr. R. L. SchildMA MRCOG
Leiter des Schwerpunkts Geburtshilfe und Perinatalmedizin · Frauenklinik der Universität Erlangen
Universitätsstraße 21–23
91054 Erlangen
Email: ralf.schild@gyn.imed.uni-erlangen.de