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Synfacts 2007(8): 0840-0840
DOI: 10.1055/s-2007-968772
DOI: 10.1055/s-2007-968772
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Ortho-Substituted Axially Chiral Biaryl Phosphorus Compounds
G. Nishida, K. Noguchi, M. Hirano, K. Tanaka*
Tokyo University of Agriculture and Technology, Japan
Further Information
Publication History
Publication Date:
24 July 2007 (online)
Significance
The Tanaka group describes the catalytic asymmetric synthesis of axially chiral biaryl phosphine compounds. Use of Rh with the H8-BINAP ligand produces the products in extremely high yields with exceptionally high ee values. The reaction is performed in dichloromethane at room temperature and is complete after one hour. Tetra-ortho-substituted biaryl compounds are generated in this reaction.