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Synfacts 2007(3): 0288-0288  
DOI: 10.1055/s-2007-968274
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Catalytic Asymmetric Friedel-Crafts Alkylation of Aromatic Ethers

Contributor(s): Mark Lautens, Yann Béthuel
J.-L. Zhao, L. Liu*, Y. Sui, Y.-L. Liu, D. Wang*, Y.-J. Chen*
Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. of China
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Publication History

Publication Date:
20 February 2007 (online)

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Significance

Over the past few years, the catalytic asymmetric Friedel-Crafts reaction has attracted great interest. In particular, its use in the synthesis of chiral aromatic hydroxy(trifluoromethyl) ethyl esters have been studied because of the possible biological properties of those compounds (W. Zhuang, N. Gathergood, R. G. Hazell, K. A. Jørgensen J. Org. Chem. 2001, 66, 1009-1013). In the present article, the authors report on ligand-free conditions to reach high yields and enantio­selectivities.