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Synfacts 2007(1): 0094-0094
DOI: 10.1055/s-2006-955667
DOI: 10.1055/s-2006-955667
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York
Chiral Chromenes via Domino Oxa-Michael-Aldol Reaction
H. Li, J. Wang, T. E-Nunu, L. Zu, W. Jiang, S. Wei*, W. Wang*
University of New Mexico, Albuquerque, USA and Nanjing Normal University, P. R. of China
Further Information
Publication History
Publication Date:
15 December 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200701/lookinside/thumbnails/10.1055-s-2006-955667-1.jpg)
Significance
A one-pot reaction affording chiral chromenes is presented. It proceeds via a domino oxa-Michael-aldol reaction sequence between α,β-unsaturated aldehydes and salicylaldehydes and is promoted by diphenylpyrrolinol triethylsilyl ether. Good to excellent yields and enantioselectivities have been achieved.