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Dtsch Med Wochenschr 2006; 131(45): 2531-2540
DOI: 10.1055/s-2006-955046
CME-Beitrag | Review article
Gastroenterologie
© Georg Thieme Verlag KG Stuttgart · New York

Funktionelle Magen-Darm-Erkrankungen

Functional gastrointestinal disordersB. Adam1 , 2 , T. Liebregts1 , 2 , S. Bertram 1 , 2 , G. Holtmann1 , 2
  • 1University of Adelaide, Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, Adelaide, South Australia, Australia
  • 2Nerve-Gut Research Laboratory, Hanson Institute, Adelaide, South Australia, Australia
Further Information

Publication History

eingereicht: 15.9.2006

akzeptiert: 26.10.2006

Publication Date:
07 November 2006 (online)

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Schlüsselwörter

Reizdarm - Reizmagen

Key words

irritable bowel syndrome - functional dyspepsia

Literatur

  • 1 Adam B, Liebregts T, Best J, Bechmann L, Lackner C, Neumann J, Koehler S, Holtmann G. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model.  Scand J Gastroenterol. 2006;  41 155-160
    Google Scholar
  • 2 Adam B, Liebregts T, Gschossmann J M, Krippner C, Scholl F, Ruwe M, Holtmann G. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model.  Pain. 2006;  123 179-186
    Google Scholar
  • 3 Agreus L, Svardsudd K, Nyren O, Tibblin G. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time.  Gastroenterology. 1995;  109 671-680
    Google Scholar
  • 4 Arents N L, Thijs J C, van Zwet A A. et al . Approach to treatment of dyspepsia in primary care: a randomized trial comparing „test-and-treat” with prompt endoscopy.  Arch Intern Med. 2003;  163 1606-1612
    Google Scholar
  • 5 Berger M Y, van der Velden J J, Lijmer J G, de Kort H, Prins A, Bohnen A M. Abdominal symptoms: do they predict gallstones? A systematic review.  Scand J Gastroenterol. 2000;  35 70-76
    Google Scholar
  • 6 Bundy R, Walker A F, Middleton R W, Marakis G, Booth J C. Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis.  J Altern Complement Med. 2004;  10 667-669
    Google Scholar
  • 7 Camilleri M, Chey W Y, Mayer E A. et al . A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome.  Arch Intern Med. 2001;  161 1733-1740
    Google Scholar
  • 8 Camilleri M, Northcutt A R, Kong S, Dukes G E, McSorley D, Mangel A W. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial.  Lancet. 2000;  355 1035-1040
    Google Scholar
  • 9 Camilleri M. Review article: tegaserod.  Aliment Pharmacol Ther. 2001;  15 277-289
    Google Scholar
  • 10 Coffin B, Farmachidi J P, Rueegg P, Bastie A, Bouhassira D. Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects.  Aliment Pharmacol Ther. 2003;  17 577-585
    Google Scholar
  • 11 Corsetti M, Caenepeel P, Fischler B, Janssens J, Tack J. Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia.  Am J Gastroenterol. 2004;  99 1152-1159
    Google Scholar
  • 12 Delaney B C, Wilson S, Roalfe A. et al . Cost effectiveness of initial endoscopy for dyspepsia in patients over age 50 years: a randomised controlled trial in primary care.  Lancet. 2000;  356 1965-1969
    Google Scholar
  • 13 Drossman D A, Leserman J, Nachman G. et al . Sexual and physical abuse in women with functional or organic gastrointestinal disorders.  Ann Intern Med. 1990;  113 828-833
    Google Scholar
  • 14 Drossman D A, Toner B B, Whitehead W E. et al . Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders.  Gastroenterology. 2003;  125 19-31
    Google Scholar
  • 15 Drossman D A. Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?.  Am J Med. 1999;  107 41S-50S
    Google Scholar
  • 16 Ford A C, Qume M, Moayyedi P. et al . Helicobacter pylori „test and treat” or endoscopy for managing dyspepsia: an individual patient data meta-analysis.  Gastroenterology. 2005;  128 1838-1844
    Google Scholar
  • 17 Gwee K A. Irritable bowel syndrome in developing countries-a disorder of civilization or colonization?.  Neurogastroenterol Motil. 2005;  17 317-324
    Google Scholar
  • 18 Hammer J, Eslick G D, Howell S C, Altiparmak E, Talley N J. Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsia.  Gut. 2004;  53 666-672
    Google Scholar
  • 19 Holtmann G, Gschossmann J, Buenger L, Gerken G, Talley N J. Do changes in visceral sensory function determine the development of dyspepsia during treatment with aspirin?.  Gastroenterology. 2002;  123 1451-1458
    Google Scholar
  • 20 Holtmann G, Gschossmann J, Karaus M. et al . Randomised double-blind comparison of simethicone with cisapride in functional dyspepsia.  Aliment Pharmacol Ther. 1999;  13 1459-1465
    Google Scholar
  • 21 Holtmann G, Talley N J, Liebregts T, Adam B, Parow C. A placebo-controlled trial of itopride in functional dyspepsia.  N Engl J Med. 2006;  354 832-840
    Google Scholar
  • 22 Lembo A J, Olden K W, Ameen V Z, Gordon S L, Heath A T, Carter E G. Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials.  Clin Gastroenterol Hepatol. 2004;  2 675-682
    Google Scholar
  • 23 Liebregts T, Adam B, Bertel A, Lackner C, Neumann J, Talley N J, Gerken G, Holtmann G. Psychological stress and the severity of post-inflammatory visceral hyperalgesia.  Eur J Pain. 2006; 
    Google Scholar
  • 24 Liu J H, Chen G H, Yeh H Z, Huang C K, Poon S K. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial.  J Gastroenterol. 1997;  32 765-768
    Google Scholar
  • 25 Locke G R, Zinsmeister A R, Fett S L, Melton L J, Talley N J. Overlap of gastrointestinal symptom complexes in a US community.  Neurogastroenterol Motil. 2005;  17 29-34
    Google Scholar
  • 26 Longstreth G F, Drossman D A. Severe irritable bowel and functional abdominal pain syndromes: managing the patient and health care costs.  Clin Gastroenterol Hepatol. 2005;  3 397-400
    Google Scholar
  • 27 Longstreth G F, Thompson W G, Chey W D, Houghton L A, Mearin F, Spiller R C. Functional bowel disorders.  Gastroenterology. 2006;  130 1480-1491
    Google Scholar
  • 28 Longstreth G F, Yao J F. Irritable bowel syndrome and surgery: a multivariable analysis.  Gastroenterology. 2004;  126 1665-1673
    Google Scholar
  • 29 Madisch A, Holtmann G, Mayr G, Vinson B, Hotz J. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial.  Digestion. 2004;  69 45-52
    Google Scholar
  • 30 Madisch A, Holtmann G, Plein K, Hotz J. Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial.  Aliment Pharmacol Ther. 2004;  19 271-279
    Google Scholar
  • 31 Moayyedi P, Feltbower R, Brown J. et al. Leeds HELP Study Group . Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial.  Lancet. 2000;  355 1665-1669
    Google Scholar
  • 32 Moayyedi P, Soo S, Deeks J. et al . Eradication of Helicobacter pylori for non-ulcer dyspepsia.  Cochrane Database Syst Rev. 2005;  CD002096
    Google Scholar
  • 33 O’Donnell L J, Virjee J, Heaton K W. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate.  Bmj. 1990;  300 439-440
    Google Scholar
  • 34 O’Mahony L, McCarthy J, Kelly P. et al . Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.  Gastroenterology. 2005;  128 541-551
    Google Scholar
  • 35 Owens D M, Nelson D K, Talley N J. The irritable bowel syndrome: long-term prognosis and the physician-patient interaction.  Ann Intern Med. 1995;  122 107-112
    Google Scholar
  • 36 Saito Y A, Schoenfeld P, Locke G R. The epidemiology of irritable bowel syndrome in North America: a systematic review.  Am J Gastroenterol. 2002;  97 1910-1905
    Google Scholar
  • 37 Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia.  Am J Gastroenterol. 2003;  98 783-788
    Google Scholar
  • 38 Straus W L, Ofman J J, MacLean C. et al . Do NSAIDs cause dyspepsia? A meta-analysis evaluating alternative dyspepsia definitions.  Am J Gastroenterol. 2002;  97 1951-1958
    Google Scholar
  • 39 Tack J, Talley N J, Camilleri M, Holtmann G, Hu P, Malagelada J R, Stanghellini V. Functional gastroduodenal disorders.  Gastroenterology. 2006;  130 1466-1479
    Google Scholar
  • 40 Talley N J, Vakil N. Guidelines for the management of dyspepsia.  Am J Gastroenterol. 2005;  100 2324-2337
    Google Scholar
  • 41 Talley N J, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia?.  Am J Gastroenterol. 2001;  96 1422-1428
    Google Scholar
  • 42 Talley N J, Zinsmeister A R, Schleck C D, Melton L J. Dyspepsia and dyspepsia subgroups: a population-based study.  Gastroenterology. 1992;  102 1259-1268
    Google Scholar
  • 43 Thomson A B, Barkun A N, Armstrong D. et al . The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment - Prompt Endoscopy (CADET-PE) study.  Aliment Pharmacol Ther. 2003;  17 1481-1491
    Google Scholar
  • 44 Walker A F, Middleton R W, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study.  Phytother Res. 2001;  15 58-61
    Google Scholar
  • 45 Gonsalkorale W M, Toner B B, Whorwell P J. Cognitive Change in patients undergoing hypnotherapy for irritable bowel syndrome.  J Psychosom Res. 2004;  56 271-278
    Google Scholar
  • 46 Kuepper-Nybelen J, Thefeld W, Rothenbacher D. Patterns of alcohol consumption and Helicobacter pylory infection: results of a population based study from Germany among 6545 adults.  Aliment Pharmacol Ther. 2005;  21 57-64
    Google Scholar
  • 47 Roberts L, Wilson S, Singh S. et al . Gut-directed hypnotherapy for irritable bowel-syndrome: piloting a primary care-based randomised controlled trial.  Br J Gen Pract. 2006;  56 115-121
    Google Scholar
  • 48 van Kerkhoven L A, van Rossum L G, van Oijen M G. et al . Upper gastrointestinal endoscopy does not reassure patients with functional dyspepsia.  Endoscopy. 2006;  38 879-885
    Google Scholar

Prof. Dr. med. Gerald Holtmann

Royal Adelaide Hospital, University of Adelaide, Department of Gastroenterology, Hepatology and General Medicine

North Tce

Adelaide, SA 5000

Australia

Phone: +61/8/82222412

Fax: +61/8/82222414

Email: gerald.holtmann@adelaide.edu.au